Accelerating declines in biodiversity and unmet targets in the Convention on Biological Diversity's 2010-2020 Strategic Plan for Biodiversity are stimulating widespread calls for transformative change. Such change includes societal transitions toward sustainability, as well as in specific content of the CBD's draft Post-2020 Global Biodiversity Framework. We summarize research on transformative change and its links to biodiversity conservation, and discuss how it may influence the work of the CBD. We identify five steps to inject transformative change into the design and implementation of a new post-2020 framework: Pay attention to lessons learned from transitions research, plan for climate change, reframe area-based conservation, scale up biodiversity mainstreaming, and increase resources. These actions will transform the very nature of work under the CBD; a convention based on voluntary implementation by countries and facilitated by international administrators and experts must now accommodate a broader range of participants including businesses, Indigenous peoples, and multiple nonstate actors.
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http://dx.doi.org/10.1093/biosci/biab013 | DOI Listing |
The optimization of dosing strategies is critical for maximizing efficacy and minimizing toxicity in drug development, particularly for drugs with narrow therapeutic windows such as antibody-drug conjugates (ADCs). This study demonstrates the utility of Nectin-4-targeted positron emission tomography (PET) imaging using [ Ga]AJ647 as a non-invasive tool for real-time assessment of target engagement in enfortumab vedotin (EV) therapy for urothelial carcinoma (UC). By leveraging the specificity of [ Ga]AJ647 for Nectin-4, we quantified dynamic changes in target engagement across preclinical models and established its correlation with therapeutic outcomes.
View Article and Find Full Text PDFHealth Sci Rep
January 2025
Department of Microbiology Dr D. Y. Patil Medical College, Hospital and Research Centre, Dr D. Y. Patil Vidyapeeth (Deemed-to-be-University) Pune Maharashtra India.
Background And Aims: Artificial Intelligence (AI) beginning to integrate in healthcare, is ushering in a transformative era, impacting diagnostics, altering personalized treatment, and significantly improving operational efficiency. The study aims to describe AI in healthcare, including important technologies like robotics, machine learning (ML), deep learning (DL), and natural language processing (NLP), and to investigate how these technologies are used in patient interaction, predictive analytics, and remote monitoring. The goal of this review is to present a thorough analysis of AI's effects on healthcare while providing stakeholders with a road map for navigating this changing environment.
View Article and Find Full Text PDFJBI Evid Synth
January 2025
School of Nursing, Faculty of Health, Dalhousie University, Halifax, NS, Canada.
Objective: The objective of this review is to identify international and Nova Scotian standards of care, CPGs, and policies informing equitable health care.
Introduction: The lack of attention given to intersectional health care needs of diverse populations perpetuates health inequities among under-served groups, creating an urgent need for health care reform globally.
Inclusion Criteria: This scoping review will include standards of care, CPGs, and policies focusing on equity-related health indicators.
Stem Cell Res Ther
January 2025
School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, 10F., Teaching & Research Building, Shuang-Ho Campus, No. 301, Yuantong Rd., Zhonghe Dist., Taipei, 235, Taiwan.
Chronic liver diseases, including cirrhosis and liver failure, remain formidable challenges due to their complex progression and limited therapeutic options. Mesenchymal stem cell (MSC) therapy has emerged as a game-changing approach, leveraging its potent immunomodulatory, anti-fibrotic, and regenerative capabilities, along with the ability to transdifferentiate into hepatocytes. This review delves into the latest advances in MSC-based treatments for chronic and end-stage liver diseases, as highlighted in current clinical trials.
View Article and Find Full Text PDFBackground: Transitioning to the updated version of The Essentials has been a significant shift in nursing education, aimed at reversing national trends of declining new graduate competence. This article describes the curriculum revision journey undertaken by one program to align with the updated version of The Essentials.
Method: The university's Center for Teaching Excellence guided the redesign process using a structured, faculty-led, data-informed approach.
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