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Novel approaches to define responders to interventional treatment in hypertension: insights from the SPYRAL HTN-OFF and HTN-ON MED trials.
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January 2025
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Multiple sham-controlled clinical trials have demonstrated significant reductions in both office and 24-h blood pressure (BP) following radiofrequency renal denervation (RDN) in the uncontrolled hypertension population. Notably, the blood pressure response varies widely within individual participants, thus showing a clinical need to identify potential RDN "responders" prior to the procedure. Despite multiple analytic efforts, no single parameter, aside from baseline blood pressure, has been consistently associated with BP reduction following RDN.
View Article and Find Full Text PDFModeling of the chest wall response to prolonged bracing in pectus carinatum.
PLoS One
August 2023
Department of Mechanical Engineering, Brigham Young University, Provo, Utah, United States of America.
Pectus carinatum is a chest wall deformity that is often treated through the wearing of an external brace. The treatment of the deformity could benefit from a greater understanding of chest wall characteristics under prolonged loading. These characteristics are difficult to model directly but empirical studies can be used to create statistical models.
View Article and Find Full Text PDFIs There a Missing Link? Exploring the Effects of Institutional Pressures on Environmental Performance in the Chinese Construction Industry.
Int J Environ Res Public Health
September 2022
Institute of Management and Decision, Shanxi University, Taiyuan 030006, China.
Although institutional pressures have huge strategic implications for organizational activities, this certainly does not mean that organizations under institutional pressures can improve environmental performance automatically. Institutional pressures are critical but not sufficient to affect environmental performance directly. Therefore, additional research is needed to explore the missing link between institutional pressures and environmental performance.
View Article and Find Full Text PDFReply to: Empirical pressure-response relations can benefit assessment of safe operating spaces.
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Theoretical Physics/Complex Systems, Institute for Chemistry and Biology of the Marine Environment, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
Empirical pressure-response relations can benefit assessment of safe operating spaces.
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Stockholm Resilience Centre, Stockholm University, Stockholm, Sweden.
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