AI Article Synopsis
- Combining sodium salicylate and ethanol during specific days of pregnancy in female rats significantly increases embryolethal and teratogenic effects compared to when each is administered separately.
- The combined effect of these substances surpasses their individual embryotoxic effects, showing a higher level of danger to developing embryos.
- The malformations observed from the combined administration are similar to those caused by sodium salicylate alone, indicating that sodium salicylate primarily drives the type of defects observed.
Article Abstract
A combined administration of sodium salicylate and ethanol to female rats in threshold embryotoxic doses on the 9th, 10th, 12th and 13th days of pregnancy results in a sharp increase of embryolethal and teratogenic effects. The embryotoxic effect of sodium salicylate and ethanol at their combined injection exceeds the summational embryotoxic effect at the separate action of the preparations. The spectrum of malformations after their combined effect does not differ from that induced with sodium salicylate.
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