Elevation of HHV-6 viral load mimicking HHV-6 reactivation after second umbilical cord blood transplantation in chromosomally integrated human herpesvirus-6. | LitMetric
Human herpesvirus-6 (HHV-6) reactivation is an important complication in patients receiving umbilical cord blood transplantation (CBT). Chromosomally integrated human herpesvirus-6 (ciHHV-6) is a condition in which the complete HHV-6 genome is integrated into the host germline genome and is transmitted in a Mendelian manner. The influence of ciHHV-6 in recipients or donors in cases of CBT is unknown. We report the first case with ciHHV-6 that received CBT twice for acute lymphoblastic T-cell leukemia. HHV-6 DNA in peripheral blood leukocytes (PBLs) was examined over time through two CBTs. After the first CBT, the HHV-6 viral load was significantly reduced by conversion to PBLs derived from the first donor. During the second CBT, an increase in HHV-6 DNA in PBLs and plasma were observed. However, HHV-6 mRNA was not detected in either the sample before 2nd CBT or at the time of HHV-6 DNA elevation. It is considered that the HHV-6 DNA detected in PBLs and plasma samples might be the HHV-6 genome released due to tissue damage. This case suggests that physicians should be aware of HHV-6 DNA variability during allogeneic hematopoietic stem cell transplantation in ciHHV-6 patients.
Background: Psoriasis (PS), vitiligo (VT), and (PR) are chronic skin diseases often occurring as a consequence of exaggerated immune responses. These skin manifestations can be triggered as a result of the molecular mimicry between viral protein (s) and host protein (s), which could generate auto-antibodies. In addition, it can be hypothesised that skin diseases are manifestations of the reduced immunity that is observed in chronic hepatitis B virus (HBV)-infected individuals.
Adenovirus has been linked to acute liver failure (ALF), prompting a study on the prevalence of various viruses in children who underwent liver transplants due to liver diseases.
The study analyzed 33 liver samples, finding HHV-6 in the majority of cases, while adenovirus was only detected in one ALF case, suggesting it may not significantly contribute to liver failure.
The findings highlight HHV-6 as the most common virus in liver transplant cases, providing foundational data for understanding viral links to ALF.
* The study included 17 FM patients and 24 healthy individuals, aiming to identify potential biomarkers, detecting human herpesvirus (HHV)-6A and B in patient samples, and measuring related antibodies and cytokine levels.
* Findings indicated higher detection of HHV-6B in FM patients, particularly those with a BMI of 30 or more, along with significant differences in gut microbiome diversity between FM patients and healthy controls.
Major depressive disorder (MDD) is a global health concern with a complex etiology involving genetic, environmental and infectious factors. The exact cause of MDD remains unknown. The present study explored the association between genetic factors, human herpesvirus 6 (HHV-6) and MDD.
Long-COVID patients often develop autoimmune disorders, possibly due to reactivation of dormant herpesvirus infections post-COVID-19, which disrupts immune system regulation.
The study focused on analyzing specific markers on NK cells in 124 long-COVID patients based on the severity of their COVID-19 symptoms and the presence of HHV-6 reactivation.
Results indicated imbalances in immune response mechanisms, with those who had severe COVID and HHV-6 reactivation showing increased levels of FasL and CD38, suggesting a risk for autoimmunity and impaired immune tolerance.
