The solid-phase synthesis of Gly-Ψ[CH(CF)NH]-peptides is presented. In order to achieve this goal, the synthesis of Gly-Ψ[CH(CF)NH]-dipeptides having the C-terminus unprotected, the N-terminus protected as Fmoc- or Teoc-, and possibly side chain functionalities protected with acid-labile protecting groups has been developed. A selected small library of six peptidomimetics, encompassing analogues of biological relevant peptides, have been obtained in high purity.
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| http://dx.doi.org/10.1021/acs.joc.1c00853 | DOI Listing |
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