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ABO isoagglutinin titers in group "O" blood donors.
Asian J Transfus Sci
October 2024
Department of Transfusion Medicine, Sri Balaji Action Medical Institute, New Delhi, India.
Background: High titers of anti-A and anti-B are considered to be one reason for hemolytic transfusion reactions and ABO hemolytic disease in fetus and neonates. There is no consensus for critical ABO antibody titers to guide transfusion or transplant decisions. Implementation of ABO titer measurement can favor reduction in transfusion reactions in nongroup "O" recipients.
View Article and Find Full Text PDF[Multi-omics genetic association analysis identifies susceptibility risk gene of acute viral respiratory infections in multi-ancestry populations and screening of potential traditional Chinese medicines].
Zhongguo Zhong Yao Za Zhi
October 2024
Nanjing University of Chinese Medicine Nanjing 210023, China Jiangsu Society for Ageing Development Nanjing 210008, China.
Article Synopsis
- The study focuses on identifying genetic risk factors for acute viral respiratory infections (ARI) and integrating traditional Chinese medicine (TCM) in their prevention through multi-omics analysis across various global populations.
- Key susceptibility risk loci for influenza and COVID-19 were discovered, including COL15A1 in Europeans, and MAN1A2 and RAB1A in East Asians, highlighting the genetic diversity in ARI susceptibility.
- Potential TCMs were identified to target the druggable key susceptibility loci, emphasizing the importance of genetic studies in informing drug development and preventive strategies for ARI.
RSM01, a novel respiratory syncytial virus monoclonal antibody: preclinical characterization and results of a first-in-human, randomised clinical trial.
BMC Infect Dis
December 2024
Bill & Melinda Gates Medical Research Institute, Cambridge, MA, USA.
Background: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease among infants and young children worldwide, especially in low- and middle-income countries (LMICs). RSM01 is a novel, highly potent, half-life-extended anti-RSV monoclonal antibody (mAb) candidate primarily being developed for LMICs. Here we present the preclinical characterisation and results of a phase 1 trial of RSM01.
View Article and Find Full Text PDFPost-COVID-19 dry eye negatively impacts the patient's quality of life.
Arq Bras Oftalmol
November 2024
Department of Social Medicine, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.
Article Synopsis
- The study aimed to investigate the ophthalmological effects of dry eye disease on the quality of life of COVID-19 survivors who had been hospitalized.
- The evaluation included various tests for dry eye disease and a quality of life questionnaire, with most patients reporting severe or critical COVID-19 symptoms.
- Results showed a significant link between dry eye symptoms and lower quality of life ratings, indicating that those suffering from dry eye experienced worse overall health and well-being.
ABO gene polymorphism and COVID-19 severity: The impact on haematological complications, inflammatory markers, and lung lesions.
Hum Immunol
November 2024
Hematology and Oncology Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address:
Purpose: The study aimed to investigate the connection between an intronic variant in the ABO gene (rs657152) and the severity of COVID-19 in terms of clinical symptoms, haematological complications, inflammatory markers, and lung lesions.
Methods: After applying exclusion criteria, the study included 240 patients divided into 3 groups: 88 Outpatients, 84 Ward-hospitalized, and 68 ICU-admitted/failed patients. The tetra-ARMS PCR method was used to genotype ABO polymorphism in the patient.
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