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Alzheimers Dement
December 2024
Dokuz Eylul University Hospital Neurology Department, Izmir, Turkey.
Background: Early-onset Alzheimer's disease (EOAD), distinct from late-onset cases, tends to present with atypical cognitive decline, such as, progressive aphasia, apraxia, visuospatial and comportmental impairments,. This study aims to investigate correlations between clinical presentation and PET imaging findings in EOAD patients.
Method: A retrospective analysis was conducted on CSF confirmed EOAD patients.
The Role of Therapeutic Endoscopic Ultrasound in Management of Malignant Double Obstruction (Biliary and Gastric Outlet): A Comprehensive Review with Clinical Scenarios.
J Clin Med
December 2024
Gastroenterology and Gastrointestinal Endoscopy Division, IRCCS San Raffaele Hospital, Via Olgettina 60, 20132 Milan, Italy.
Endoscopic ultrasound (EUS)-guided interventions have revolutionized the management of malignant biliary obstruction (MBO) and gastric outlet obstruction (GOO), providing minimally invasive alternatives with improved outcomes. These procedures have significantly reduced the need for high-risk surgical interventions or percutaneous alternatives and have provided effective palliative care for patients with advanced gastrointestinal and bilio-pancreatic malignancies. EUS-guided biliary drainage (EUS-BD) techniques, including hepaticogastrostomy (EUS-HGS), choledochoduodenostomy (EUS-CDS), and antegrade stenting (EUS-AS), offer high technical and clinical success rates, with a good safety profile particularly when Endoscopic Retrograde Cholangiopancreatography (ERCP) is not feasible.
View Article and Find Full Text PDFCan we predict postoperative fever and urinary tract ınfection after retrograde ıntrarenal surgery? Results of a case control matching multicentric RIRSearch study group.
World J Urol
January 2025
Faculty of Medicine, Department of Urology, İstanbul Cerrahpaşa University, Istanbul, Turkey.
Purpose: Postoperative fever (POF)/urinary tract infection (UTI) is one of the most unpleasant and undesirable conditions for surgeons after retrograde intrarenal surgery (RIRS). RIRS is not recommended for any patient with a positive urine culture to avoid POF and UTI, but some patients may develop postoperative UTI even if the urine culture is sterile. This study investigated the predictive factors of fever and UTIs after RIRS.
View Article and Find Full Text PDFHippocampal Lesions in Male Rats Produce Retrograde Memory Loss for Over-Trained Spatial Memory but Do Not Impact Appetitive-Contextual Memory: Implications for Theories of Memory Organization in the Mammalian Brain.
J Neurosci Res
January 2025
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
Article Synopsis
- The study investigates the role of the hippocampus (HPC) and amygdala in memory formation, particularly focusing on retrograde amnesia that occurs after HPC disruption.
- Findings reveal that damage to the HPC does not affect conditioned place preference (CPP) tasks, which rely on the basolateral amygdala, suggesting that not all learning tasks require HPC involvement.
- Additional experiments using the Morris water task indicate that while HPC damage impairs performance, other memory networks can't fully compensate when certain training methods are used, highlighting the complexity of memory processing.
A Neural Circuit From Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens Mediates Inflammatory Pain in Mice.
Brain Behav
January 2025
Department of Anesthesiology & Clinical Research Center for Anesthesia and Perioperative Medicine & Key Laboratory of Anesthesia and Analgesia Application Technology, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, China.
Article Synopsis
- Inflammation-related pain alters pain sensitivity in mice, evidenced by reduced paw withdrawal thresholds and latencies in CFA-induced pain models.
- Research highlights elevated c-Fos protein expression in the paraventricular nucleus of the thalamus (PVT), indicating neuron activation due to pain stimuli.
- The study utilized optogenetics to modulate the PVT-NAc neural circuit, showing its significant role in how inflammatory pain is experienced and managed.
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