AI Article Synopsis
- Isocitrate dehydrogenase (IDH) wild-type diffuse astrocytic tumors are commonly diagnosed as glioblastomas (GBMs), with a lower myoinositol to total choline (Ins/Cho) ratio in GBMs compared to IDH-mutant gliomas.
- A study was conducted to see if a low Ins/Cho ratio correlates with poorer progression-free survival (PFS) and overall survival (OS) in patients with IDH-wild-type GBMs.
- Results showed that patients with a low Ins/Cho ratio had significantly shorter PFS and OS, suggesting that the Ins/Cho ratio may serve as a useful prognostic marker for these tumors.
Article Abstract
Isocitrate dehydrogenase (IDH) wild-type diffuse astrocytic tumors tend to be pathologically diagnosed as glioblastomas (GBMs). We previously reported that myoinositol to total choline (Ins/Cho) ratio in GBMs on magnetic resonance (MR) spectroscopy was significantly lower than that in IDH-mutant gliomas. We then hypothesized that a low Ins/Cho ratio is a poor prognosis factor in patients with GBMs, IDH-wild-type. In the present study, we calculated the Ins/Cho ratios of patients with GBMs and investigated their progression-free survival (PFS) and overall survival (OS) to determine their utility as prognostic marker. We classified patients with GBMs harboring wild-type IDH (n = 27) into two groups based on the Ins/Cho ratio, and compared patient backgrounds, pathological findings, PFS, OS, and copy number aberrations between the high and low Ins/Cho groups. Patients with GBMs in the low Ins/Cho ratio group indicated shorter PFS (P = 0.021) and OS (P = 0.048) than those in the high Ins/Cho group. Multivariate analysis demonstrated that the Ins/Cho ratio was significantly correlated with PFS (hazard ratio 0.24, P = 0.028). In conclusion, the preoperative Ins/Cho ratio can be used as a novel potential prognostic factor for GBM, IDH-wild-type.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365238 | PMC |
| http://dx.doi.org/10.2176/nmc.oa.2020-0312 | DOI Listing |
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- Isocitrate dehydrogenase (IDH) wild-type diffuse astrocytic tumors are commonly diagnosed as glioblastomas (GBMs), with a lower myoinositol to total choline (Ins/Cho) ratio in GBMs compared to IDH-mutant gliomas.
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- Results showed that patients with a low Ins/Cho ratio had significantly shorter PFS and OS, suggesting that the Ins/Cho ratio may serve as a useful prognostic marker for these tumors.
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