[Figure: see text].
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http://dx.doi.org/10.1161/ATVBAHA.121.316404 | DOI Listing |
Arterioscler Thromb Vasc Biol
July 2021
Division of Cardiology, Department of Internal Medicine II (S.C., S.S., I.M.L.), Medical University of Vienna, Austria.
[Figure: see text].
View Article and Find Full Text PDFRev Med Chir Soc Med Nat Iasi
September 2018
Nowadays, tooth extraction has become a frequently performed surgical procedure whose most common postoperative outcome is alveolar bone atrophy. To reduce the bone dimensional changes, localized alveolar ridge augmentation or socket preservation with bone grafting is required. The socket may be filled with synthetic grafts, xenografts, autografts, allografts, autologous platelet concentrate.
View Article and Find Full Text PDFThromb Res
May 1990
Abbott Laboratories, Abbott Park, Il 60064.
Low molecular weight two-chain urokinase is a 33-kD plasminogen activator, which has no innate affinity for fibrin and consequently, its use to facilitate lysis of blood clots may lead to systemic activation of plasminogen. In order to impart clot affinities to this urokinase form (UK) we have generated two novel fibrin-binding derivatives by partially reducing UK and exchanging the native disulfide-linked peptide A with peptide A analogs. The peptide A analogs contained the fibrin-adherent fibrin-derived sequences, GPRP (derived from positions 17-20 of the fibrinogen alpha chain) or QAGDV (407-411 sequence of the fibrinogen gamma chain), each coupled through amino-hexanoic acid to a synthetic peptide, LKFQCGQK, containing the Leu 144-Lys 158 sequence of the urinary plasminogen activator A Chain.
View Article and Find Full Text PDFJ Pharmacol Exp Ther
December 1987
Department of Medicine, Rhode Island Hospital, Providence.
Decreased angiotensin converting enzyme (ACE) activity is a common finding in patients with adult respiratory distress syndrome and in animal models of lung injury. The nature of this effect is unknown. Intravascular fibrin, also a common finding in lung injury, is degraded to small peptides by proteolytic enzymes.
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