Introduction: Atopic dermatitis is a common skin disease characterized by altered cutaneous immunity in which patients often exhibit lower skin microbiota diversity compared to healthy skin and are prone to colonization by Staphylococcus aureus. Apple cider vinegar has been shown to have antibacterial effects; however, its effects on the skin microbiome have not previously been well-described.
Objectives: We aimed to examine the effects of topical dilute apple cider vinegar soaks on Staphylococcus aureus abundance, skin bacterial microbiome composition, and skin bacterial microbiome diversity in atopic dermatitis participants compared to healthy skin.
Methods: Eleven subjects with atopic dermatitis and 11 healthy controls were enrolled in this randomized, non-blinded, single-institution, split-arm pilot study. Subjects soaked one forearm in dilute apple cider vinegar (0.5% acetic acid) and the other forearm in tap water for 10 minutes daily. Skin bacteria samples were collected from subjects' volar forearms before and after 14 days of treatment. 16S sequencing was used to analyze Staphylococcus aureus abundance and skin bacterial microbiome composition, and alpha diversity of microbiota were determined using Shannon diversity index.
Results: There was no difference in skin bacterial microbiome in atopic dermatitis subjects after 2 weeks of daily water or apple cider vinegar treatments (p = 0.056 and p = 0.22, respectively), or in mean abundance of S. aureus on apple cider vinegar-treated forearms (p = 0.60). At 2 weeks, the skin bacterial microbiomes of healthy control subjects were not significantly different from the skin bacterial microbiome of atopic dermatitis subjects (p = 0.14, 0.21, 0.12, and 0.05).
Conclusions: Our results suggest that daily soaks in 0.5% apple cider vinegar are not an effective method of altering the skin bacterial microbiome in atopic dermatitis. Further studies are needed to explore the effects of different concentrations of apple cider vinegar on skin microflora and disease severity.
Trial Number: UVA IRB-HSR #19906.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8172074 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252272 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Forest Fruits Organic Honey Vinegar (FFOHV) is a spontaneously fermented (yeast) and acetified (Acetic Acid Bacteria-AAB) Miombo Woodland honey vinegar developed in Zambia. Live vinegars containing live microbial cultures are marketed for their probiotic health benefits. The correlation between a well-developed gut microbiome and human health is well studied and fermented products such as live vinegar containing AAB contribute to a healthy gut microbiome.
View Article and Find Full Text PDFAntimicrobial efficacy of natural-based endodontic solutions: a systematic review with a network meta-analysis.
Braz Oral Res
January 2025
Universidade Estadual Paulista - Unesp, School of Dentistry, Department of Restorative Dentistry, Araraquara, SP, Brazil.
This systematic review aims to provide preclinical evidence of the antimicrobial efficacy of natural endodontic solutions (NES) compared to sodium hypochlorite (NaOCl) and chlorhexidine (CHX) against Enterococcus faecalis. The study followed the PRISMA guidelines and had a registered protocol (PROSPERO - CRD42021224022). The inclusion criteria comprised ex vivo studies simulating root canal irrigation to assess the standardized mean difference of colony-forming units (CFUs).
View Article and Find Full Text PDFNovel natural and economic approach for controlling methicillin-resistant Staphylococcus aureus using apple cider vinegar.
Microb Pathog
January 2025
Department of Bacteriology, Immunology, and Mycology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt. Electronic address:
Article Synopsis
- MRSA is a significant health threat due to its role in infectious mastitis in livestock and its ability to resist multiple antibiotics, which complicates treatment efforts globally.
- A study conducted in Egypt found that cows have a higher incidence of mastitis than buffaloes, with treatment costs totaling around 82 million EGP from 2016 to 2021.
- The use of apple cider vinegar (ACV) showed promising antibacterial effects against MRSA, with effective inhibition rates, suggesting it could be a viable alternative to conventional antibiotics.
Effects of Various Solutions on Color Stability and Surface Hardness of Nanohybrid Dental Composite Under Simulated Oral Conditions.
J Contemp Dent Pract
July 2024
Department of Conservative Dentistry and Endodontics, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Mangaluru, Karnataka, India, Phone: +91 9902634770, e-mail:
Aim: This study evaluated effects of various solutions on color stability and surface hardness of a nanohybrid dental composite in simulated oral environments.
Materials And Methods: Sixty-four composite disks were fabricated and randomly allocated into eight groups ( = 8 per group): Artificial saliva (AS), Biotene (B), passion fruit juice (PFJ), orange juice (OJ), Sprite (S), Coca-Cola (CO), apple cider vinegar (ACV), and cranberry juice (CJ). Specimens were immersed in respective solutions at 37°C for 28 days.
Inhibitory Potency of Chlorogenic Acid from Apple Cider Vinegar Against Alzheimer's Disease: Molecular Docking and Dynamics Validation.
J Am Nutr Assoc
November 2024
Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Ranchi, India.
Objective: The primary cause of memory loss is Alzheimer's disease (AD). Recent studies have shown that natural compounds like apple cider vinegar (ACV) have anti-Alzheimer's capabilities. Essential components of ACV, such as gallic acid and chlorogenic acid, may be in charge of the drug's pharmacological effects.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!