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Thoracoscopic resection of primary mediastinal liposarcoma: a case report and literature review.

J Cardiothorac Surg

January 2025

Department of Cardiothoracic Surgery, The First People's Hospital of Neijiang, No. 1866, West Section of Hanan Avenue, Shizhong District, Neijiang, Sichuan, 641000, P.R. China.

Background: Primary mediastinal liposarcomas (PLMs) are extremely rare. Patients typically present with symptoms caused by tumor size, as the mass can compress surrounding tissues and organs. Here, we report a case of a large primary mediastinal liposarcoma that was successfully resected thoracoscopically.

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A 61-year-old woman presented to our team with giant mediastinal liposarcoma causing compression of the esophagus, bronchus, and left atrium. Given the patient's advanced presentation and reduced cardiac reserve, rescue venoarterial extracorporeal membrane oxygenation was used in addition to standard robotic-assisted thoracic surgery for mass resection.

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Article Synopsis
  • Liposarcoma is a rare malignant tumor that can occur in the mediastinum, and most existing information comes from scattered reports rather than extensive studies.
  • A 51-year-old man presented with respiratory symptoms and was found to have a large mediastinal mass that was misidentified as a teratoma; after surgery, he was diagnosed with dedifferentiated liposarcoma.
  • Despite surgical intervention and chemotherapy, the patient experienced rapid recurrence and ultimately died four months post-surgery, highlighting the need for correct diagnosis and treatment strategies for this aggressive condition.*
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Article Synopsis
  • * A case study of a 36-year-old woman showed she had worsening shortness of breath and swelling, leading to a diagnosis of a large anterior mediastinal mass that was successfully surgically removed.
  • * The significance of this case highlights the need for early diagnosis of mediastinal liposarcoma in patients with respiratory symptoms, as prompt treatment can greatly improve patient outcomes.
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Liposarcomas (LPSs) are rare malignant tumors of adipocytic origin, primarily occurring in the extremities and retroperitoneum, with thoracic involvement being exceptionally rare. This case report details the surgical management and outcomes of a recurrent intrathoracic LPS in a 65-year-old male with a history of previous mediastinal tumor resection. CT imaging revealed a recurrent tumor extending into the left pleura.

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