The development of a stereoselective method for the rapid assembly of structurally complex molecules remains fascinating and challenging in synthetic organic chemistry. Here, we report an enantioselective domino reaction between 3-vinylindole and -quinone methide for the preparation of 3-indolyl cyclopenta[]indoles containing multiple chiral centers. Chiral imidodiphosphoric acids enable this cascade asymmetric process, delivering a series of products with excellent yields (≤99%), enantioselectivities (≤99%), and diastereoselectivities (≤20:1 dr).
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| http://dx.doi.org/10.1021/acs.orglett.1c01600 | DOI Listing |
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Enantioselective Heck/Tsuji-Trost reaction of flexible vinylic halides with 1,3-dienes.
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