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| http://dx.doi.org/10.1186/s12961-021-00740-y | DOI Listing |
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The Virtual Client Experience Survey for Mental Health and Addictions: Revalidation of a Survey to Measure Client and Family Experiences of Virtual Care.
J Med Internet Res
January 2025
Centre for Addiction and Mental Health, Toronto, ON, Canada.
Background: The onset of the COVID-19 pandemic precipitated a rapid shift to virtual care in health care settings, inclusive of mental health care. Understanding clients' perspectives on virtual mental health care quality will be critical to informing future policies and practices.
Objective: This study aimed to outline the process of redesigning and validating the Virtual Client Experience Survey (VCES), which can be used to evaluate client and family experiences of virtual care, specifically virtual mental health and addiction care.
Stability of expansion effects following Miniscrew-assisted Rapid Palatal expansion: a prospective longitudinal cohort study.
Oral Maxillofac Surg
January 2025
Department of Orthodontics and Craniofacial Biology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Purpose: This study aimed to evaluate the dental and skeletal stability one year after Miniscrew-Assisted Rapid Palatal Expansion (MARPE) by using 3D image data.
Methods: Patients with transverse maxillary deficiency from the age of 16 onwards were enrolled consecutively in this prospective longitudinal cohort study. The MARPE appliance was digitally and individually designed and fabricated.
BACT: nonparametric Bayesian cell typing for single-cell spatial transcriptomics data.
Brief Bioinform
November 2024
Institute of Statistics and Big Data, Renmin University of China, No. 59 Zhongguancun Street, 100872 Beijing, China.
The spatial transcriptomics is a rapidly evolving biological technology that simultaneously measures the gene expression profiles and the spatial locations of spots. With progressive advances, current spatial transcriptomic techniques can achieve the cellular or even the subcellular resolution, making it possible to explore the fine-grained spatial pattern of cell types within one tissue section. However, most existing cell spatial clustering methods require a correct specification of the cell type number, which is hard to determine in the practical exploratory data analysis.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Tulane University, New Orleans, LA, USA.
Background: Clinical studies indicate that mid-life dietary patterns are a risk factor for cognitive decline. Adherence to a Mediterranean diet (MeDi) may promote healthy brain aging in contrast to a Western diet (WD), yet these diets have not been examined in pre-clinical models. We hypothesized that consumption of the MeDi would have better cognitive performance compared to the Western diet in middle-aged rats.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Amsterdam Neuroscience, Brain Imaging, Amsterdam, Netherlands.
Background: The hippocampus is highly vulnerable to amyloid-b (Aβ) and phosphorylated tau (p-tau), and shows synaptic loss in Alzheimer's disease (AD). Moreover, the loss of synapses correlates strongly with cognitive decline and leads to neuronal network dysfunction. Here, we aim to map the selective synaptic loss in hippocampal and parahippocampal subregions in AD and its association to the severity of neuropathology, axonal damage and cognitive decline.
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