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Design, Synthesis, and Biological Evaluation of Novel 6-Benzo[]chromen-6-one Derivatives as Potential Phosphodiesterase II Inhibitors. | LitMetric
Urolithins (hydroxylated 6-benzo[]chromen-6-ones) are the main bioavailable metabolites of ellagic acid (EA), which was shown to be a cognitive enhancer in the treatment of neurodegenerative diseases. As part of this research, a series of alkoxylated 6-benzo[]chromen-6-one derivatives were designed and synthesized. Furthermore, their biological activities were evaluated as potential PDE2 inhibitors, and the alkoxylated 6-benzo[]chromen-6-one derivative was found to have the optimal inhibitory potential (IC: 3.67 ± 0.47 μM). It also exhibited comparable activity in comparison to that of BAY 60-7550 in vitro cell level studies.
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