AI Article Synopsis
- The study estimated the cure proportions and survival rates of patients with stage II-III cutaneous melanoma (CM) in Sweden.
- Significant differences were found in the standardized cure proportions among the various sub-stages, with stage IIA showing the highest cure rate.
- The findings highlight a poor prognosis for certain sub-groups, indicating low cure rates after surgery for stages IIB-C of CM.
Article Abstract
Background: Cure proportion represents the proportion of patients who experience the same mortality rate as the general population and can be estimated together with the survival of the proportion experiencing excess mortality (the uncured). The aim was to estimate the cure proportions and survival among uncured stage II-III cutaneous melanoma (CM) patients.
Methods: 1- and 5-year relative survival ratios, cure proportions and the median survival times of uncured stage II-III CM patients in Sweden ( = 6466) were calculated based on data from the nationwide population-based Swedish Melanoma Register 2005-2013 with a follow-up through 2018.
Results: Stages IIB and IIC showed significant differences in standardized cure proportions vs. stage IIA CM (0.80 (95% CI 0.77-0.83) stage IIA; 0.62 (95% CI 0.59-0.66) stage IIB; 0.42 (95% CI 0.37-0.46) for stage IIC). Significant differences in standardized cure proportions were found for stages IIIB and IIIC-D CM vs. stage IIIA (0.76 (95% CI 0.68-0.84) stage IIIA; 0.52 (95% CI 0.45-0.59) stage IIIB; 0.35 (95% CI 0.30-0.39) for stage IIIC-D).
Conclusions: The results are emphasizing the poor prognosis with low proportions cured by surgery only for sub-groups of stage II-III CM, specifically within stages IIB-C CM.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158378 | PMC |
| http://dx.doi.org/10.3390/cancers13102456 | DOI Listing |
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