Alpha B-crystallin (CRYAB, HSPB5) belongs to the small heat shock protein (HSP) family and is highly expressed in various human cancers, suggesting a crucial role in tumor progression. However, few studies have examined CRYAB expression in colorectal cancer (CRC). In the present study, we investigated the relationship between CRYAB expression and the clinicopathological features of CRC samples. We comparatively analyzed CRYAB protein expression in 111 CRC tissues and normal adjacent colonic tissue, observing that it was significantly lower in CRC tissues than in corresponding non-cancerous tissues. Moreover, immunohistochemical analysis showed a significant correlation between CRYAB expression and high histological grade G3 ( = 0.033). In summary, our results point to its possible application as a prognostic biomarker in CRC patients.
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| http://dx.doi.org/10.3390/diagnostics11050896 | DOI Listing |
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- Protein quality control (PQC) is essential for the function of heart cells, and certain mutations (like R120G in CRYAB and P209L in BAG3) can lead to the buildup of harmful protein aggregates and heart diseases.
- The study explored how these protein aggregates are taken up by mitochondria and removed through a process called mitophagy, especially in mice lacking the TRAF2 protein, which is necessary for mitophagy.
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