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The Vaginal Microbiota, Bacterial Biofilms and Polymeric Drug-Releasing Vaginal Rings. | LitMetric

AI Article Synopsis

  • The vaginal microbiota is crucial for vaginal health, but interactions with drug delivery systems like vaginal rings are not well understood.
  • Drug-releasing vaginal rings are marketed for hormonal contraception and other therapies, yet limited research on bacterial adherence and biofilm formation on these rings has been conducted over the past 50 years.
  • This article reviews key aspects including the vaginal microbiome, biofilm formation, polymeric materials used in vaginal rings, and necessary regulatory considerations for their development.

Article Abstract

The diversity and dynamics of the microbial species populating the human vagina are increasingly understood to play a pivotal role in vaginal health. However, our knowledge about the potential interactions between the vaginal microbiota and vaginally administered drug delivery systems is still rather limited. Several drug-releasing vaginal ring products are currently marketed for hormonal contraception and estrogen replacement therapy, and many others are in preclinical and clinical development for these and other clinical indications. As with all implantable polymeric devices, drug-releasing vaginal rings are subject to surface bacterial adherence and biofilm formation, mostly associated with endogenous microorganisms present in the vagina. Despite more than 50 years since the vaginal ring concept was first described, there has been only limited study and reporting around bacterial adherence and biofilm formation on rings. With increasing interest in the vaginal microbiome and vaginal ring technology, this timely review article provides an overview of: (i) the vaginal microbiota, (ii) biofilm formation in the human vagina and its potential role in vaginal dysbiosis, (iii) mechanistic aspects of biofilm formation on polymeric surfaces, (iv) polymeric materials used in the manufacture of vaginal rings, (v) surface morphology characteristics of rings, (vi) biomass accumulation and biofilm formation on vaginal rings, and (vii) regulatory considerations.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161251PMC
http://dx.doi.org/10.3390/pharmaceutics13050751DOI Listing

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