Fungal infections remain a major health concern with aromatic plants and their metabolites standing out as promising antifungal agents. The present study aims to assess, for the first time, the antifungal and anti-inflammatory potential of subsp. (Brot.) H.Wolff essential oil from Portugal. The oil obtained by hydrodistillation and characterized by GC-MS, showed high amounts of monoterpene hydrocarbons, namely α-pinene (29.0-36.0%), β-pinene (26.1-30.7%) and limonene (10.5-13.5%). The antifungal potential was assessed, according to CLSI guidelines, against several clinical and collection strains. The essential oil showed a broad fungicidal effect being more potent against and dermatophytes. Moreover, a significant germ tube inhibition was observed in as well as a disruption of mature biofilms, thus pointing out an effect of the oil against relevant virulent factors. Furthermore, fungal ultrastructural modifications were detected through transmission electron microscopy, highlighting the nefarious effect of the oil. Of relevance, the oil also evidenced anti-inflammatory activity through nitric oxide inhibition in macrophages activated with lipopolysaccharide. In addition, the essential oil's bioactive concentrations did not present toxicity towards macrophages. Overall, the present study confirmed the bioactive potential of subsp. essential oil, thus paving the way for the development of effective drugs presenting concomitantly antifungal and anti-inflammatory properties.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156192 | PMC |
| http://dx.doi.org/10.3390/antibiotics10050592 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Storage and controlled release of fragrances maintaining a constant ratio of volatile compounds.
Anal Methods
November 2017
KIST Europe GmbH, 66123, Saarbrücken, Germany.
Controlled fragrance release at the right time, in the right place, depending on the context remains a technological challenge in the areas of psychophysiology, biochemistry and the entertainment industry. In this study, we demonstrate how bulk poly(dimethylsiloxane) (PDMS) templates may effectively take up and retain volatile organic compounds of essential orange oil in the original form without significantly shifting the scent profile. This is done depending on the sampling approach that follows a controllable and slow fragrance release maintaining a constant ratio of volatile compounds in a template-thickness, temperature and time-dependent manner.
View Article and Find Full Text PDFDietary rosemary oil with/without zymogen forte improves water quality, growth hormones, immune-physiological response, stress resilience, and health status of Chelon ramada grown in groundwater.
BMC Vet Res
January 2025
Aquaculture Division, National Institute of Oceanography and Fisheries, NIOF, Cairo, Egypt.
With freshwater resources becoming scarce worldwide, mariculture is a promising avenue to sustain aquaculture development, especially by incorporating brackish and saline groundwater (GW) use into fish farming. A 75-day rearing trial was conducted to evaluate fish growth, immune response, overall health, and water quality of Chelon ramada cultured in brackish GW and fed on a basal diet (BD) augmented with rosemary oil (RO) or RO + zymogen forte™ (ZF) as an anti-flatulent. Five treatments were administrated in triplicate: T1: fish-fed BD without additives (control group); T2: fish-fed BD + 0.
View Article and Find Full Text PDFDual-mode CRISPR/Cas12a-assisted fluorescent and lateral flow aptasensor based on a newly truncated aptamer for Fumonisin B1 detection.
Int J Biol Macromol
January 2025
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address:
As a Group 2B carcinogen, accurate and efficient detection for Fumonisin B1 (FB1) is essential. The emergence of aptamers presents a viable solution to meet this demand. In this study, a truncated aptamer named Apt40 was developed, showcasing remarkable binding affinity to FB1.
View Article and Find Full Text PDFCorrigendum to "Fabrication and characterization of pullulan/tapioca starch-based antibacterial films incorporated with Litsea cubeba essential oil for meat preservation" [Int. J. Biol. Macromol. 268 (2024) 131775].
Int J Biol Macromol
January 2025
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China; State Key Laboratory of Utilization of Woody Oil Resource, Hunan Academy of Forestry, Changsha 410007, China. Electronic address:
Food groups, macronutrient intake and objective measures of total carotenoids and fatty acids in 16-to-24-year-olds following different plant-based diets compared to an omnivorous diet.
PLoS One
January 2025
Department of Nutrition and Public Health, Faculty of Health and Sport Science, University of Agder, Kristiansand, Norway.
Background: Knowledge about the diet quality among youth who follow different types of plant-based diets is essential to understand whether support is required to ensure a well-planned diet that meets their nutritional needs. This study aimed to investigate how food groups, macronutrient intake, and objective blood measures varied between Norwegian youth following different plant-based diets compared to omnivorous diet.
Methods: Cross-sectional design, with healthy 16-to-24-year-olds (n = 165) recruited from the Agder area in Norway, following a vegan, lacto-ovo-vegetarian, pescatarian, flexitarian or omnivore diet.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!