In order to improve pharmaceutical properties of drugs, complexes are synthesized as combinations with other chemical substances. The complexes of fenamic acid and its derivatives, such as mefenamic-, tolfenamic- and flufenamic acid, with acridine were obtained and the X-ray structures were discussed. Formation of the crystals is determined by the presence of the intermolecular O-HN hydrogen bond that occur between fenamic acids and acridine. Intermolecular interactions stabilizing the crystals such as ππ stacking, C-HX (X = O, Cl) intermolecular hydrogen bonds as well as C-Hπ and other dispersive interactions were analyzed by theoretical methods: the quantum theory of atoms in molecules (QTAIM) and noncovalent interaction (NCI) approaches.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8156396 | PMC |
| http://dx.doi.org/10.3390/molecules26102956 | DOI Listing |
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