AI Article Synopsis
- Subcutaneous fat necrosis is a rare condition primarily seen in term newborns, often linked to complications like birth asphyxia and meconium aspiration, as well as treatments like therapeutic hypothermia.
- The most serious complication is hypercalcemia, which can become life-threatening and lead to nephrocalcinosis, a condition where calcium deposits form in the kidneys.
- The document discusses a case of a newborn who developed late-onset severe hypercalcemia and nephrocalcinosis after therapeutic hypothermia, emphasizing the need for close monitoring to prevent kidney damage.
Article Abstract
Subcutaneous fat necrosis is an uncommon benign panniculitis affecting more commonly full-term newborns. It has been associated with birth asphyxia and meconium aspiration, as well as therapeutic hypothermia. Although the prognosis is generally favorable, complications such as hypercalcemia, thrombocytopenia, hypoglycemia and hypertriglyceridemia may complicate its course. The most serious complication is hypercalcemia that may reach life threatening levels and can be associated with nephrocalcinosis. We thereby describe a case of subcutaneous fat necrosis after therapeutic hypothermia, which presented with late-onset refractory severe hypercalcemia and persistent nephrocalcinosis during the follow up of the patient. Due to the risk of the development of chronic kidney disease, we highlight the importance of careful monitoring of hypercalcemia and review the literature of subcutaneous fat necrosis related to nephrocalcinosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151818 | PMC |
| http://dx.doi.org/10.3390/children8050374 | DOI Listing |
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