Sprinkling salt on mitochondria: The metabolic and pathophysiological roles of mitochondrial Na signaling mediated by NCLX.

Cell Calcium

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, 84105, Israel. Electronic address:

Published: May 2021

NCLX, the mitochondrial Na/Ca transporter is a key player in Ca signaling. However, its role in Na signaling is poorly understood. In this review we focus on Na signaling by NCLX, and discuss recent physiological and pathophysiological roles attributed to the Na influx into mitochondria.

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http://dx.doi.org/10.1016/j.ceca.2021.102416DOI Listing

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