AI Article Synopsis
- The research suggests that gut microbiota may influence the dorsolateral prefrontal cortex (DLPFC), but few studies have explored how repetitive transcranial magnetic stimulation (rTMS) can alter brain-gut connections.
- In the study with 25 healthy male participants, rTMS applied to the right or left DLPFC was found to significantly affect visceral sensations and emotional responses elicited by rectal stimulation.
- Specifically, low frequency rTMS to the right DLPFC reduced visceral sensations, while high frequency rTMS increased certain hormones and induced rectal contractions, highlighting the potential of rTMS to modify brain-gut interactions in humans.
Article Abstract
Gut microbiota may affect function of the dorsolateral prefrontal cortex (DLPFC). However, there have been a few studies on modification of brain-gut interactions with repetitive transcranial magnetic stimulation (rTMS) to the DLPFC. We hypothesized that stimulation of the right or left DPFC by rTMS modifies the brain-gut interactions in humans. Subjects were 25 healthy males. Viscerosensory evoked potential (VEP) with sham (0 mA) or actual (30 mA) electrical stimulation (ES) of the rectum was taken after sham, low frequency rTMS at 0.1 Hz, and high frequency rTMS at 10 Hz to the right or left DLPFC. Rectal tone was measured with a rectal barostat. Visceral perception and emotion were analyzed using ordinates scale, rectal barostat, and viscerosensory evoked potential. Low frequency rTMS to the right DLPFC significantly reduced the visceral sensation and emotion composite score evoked by ES at 30 mA (p < 0.05). Plasma ACTH was significantly increased by high frequency rTMS to the right or left DLPFC (p < 0.05). Rectal fine contractions were significantly induced by low frequency rTMS to the right or left DLPFC and high frequency rTMS to the right DLPFC (p < 0.05). These results suggest that stimulation of the right or left DPFC by rTMS modifies the brain-gut interactions in humans.
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| http://dx.doi.org/10.1016/j.neures.2021.05.013 | DOI Listing |
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