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Development and Characterization of Dual-Loaded Niosomal Ion-Sensitive In Situ Gel for Ocular Delivery.
Gels
December 2024
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.
The study investigates the development and characterization of dual-loaded niosomes incorporated into ion-sensitive in situ gel as a potential drug delivery platform for ophthalmic application. Cannabidiol (CBD) and epigallocatechin-3-gallate (EGCG) simultaneously loaded niosomes were prepared via the thin film hydration (TFH) method followed by pulsatile sonication and were subjected to comprehensive physicochemical evaluation. The optimal composition was included in a gellan gum-based in situ gel, and the antimicrobial activity, in vitro toxicity in a suitable corneal epithelial model (HaCaT cell line), and antioxidant potential of the hybrid system were further assessed.
View Article and Find Full Text PDFModel organisms for investigating the functional involvement of NRF2 in non-communicable diseases.
Redox Biol
December 2024
Jacqui Wood Cancer Centre, Division of Cancer Research, School of Medicine, University of Dundee, Dundee, UK; Department of Pharmacology and Molecular Sciences and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Non-communicable chronic diseases (NCDs) are most commonly characterized by age-related loss of homeostasis and/or by cumulative exposures to environmental factors, which lead to low-grade sustained generation of reactive oxygen species (ROS), chronic inflammation and metabolic imbalance. Nuclear factor erythroid 2-like 2 (NRF2) is a basic leucine-zipper transcription factor that regulates the cellular redox homeostasis. NRF2 controls the expression of more than 250 human genes that share in their regulatory regions a cis-acting enhancer termed the antioxidant response element (ARE).
View Article and Find Full Text PDFBacterial Cellulose/Graphene Oxide/Hydroxyapatite Biocomposite: A Scaffold from Sustainable Sources for Bone Tissue Engineering.
ACS Appl Mater Interfaces
December 2024
Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, třída Tomáše Bati 5678, 76001 Zlín, Czech Republic.
Bone tissue engineering demands advanced biomaterials with tailored properties. In this regard, composite scaffolds offer a strategy to integrate the desired functionalities. These scaffolds are expected to provide sufficient cellular activities while maintaining the required strength necessary for the bone repair for which they are intended.
View Article and Find Full Text PDFNanoparticle-Composed Photosensitive Thin Films Based on ZnO.
Materials (Basel)
November 2024
Institute of Electronics, Bulgarian Academy of Sciences, 72 Tsarigradsko Chaussee, 1784 Sofia, Bulgaria.
In this work, atmospheric pulsed laser deposition was used to prepare photosensitive elements. This technology is a practical and relatively inexpensive way of obtaining highly porous nanostructures composed of nanoparticles or nanoaggregates characterized by a large surface-to-volume ratio. Samples were produced via laser nanosecond or picosecond laser ablation of pure ZnO or mixed ZnO-TiO targets on quartz substrates with pre-deposited gold electrodes.
View Article and Find Full Text PDFThe Formation of γ-Valerolactone from Renewable Levulinic Acid over Ni-Cu Fly Ash Zeolite Catalysts.
Molecules
December 2024
HUN-REN Research Centre for Natural Sciences, Institute of Materials and Environmental Chemistry, Magyar Tudósok Krt. 2, 1117 Budapest, Hungary.
Zeolites with different structures (P1, sodalite, and X) were synthesized from coal fly ash by applying ultrasonically assisted hydrothermal and fusion-hydrothermal synthesis. Bimetallic catalysts, containing 5 wt.% Ni and 2.
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