AI Article Synopsis
- - Photocatalytic hydrogen atom transfer is an effective method for efficiently modifying organic molecules with specific focus on C(sp)-H functionalization.
- - This study introduces a novel approach that combines decatungstate photocatalysis with radical-polar crossover to facilitate direct oxidative C(sp)-H heteroarylation.
- - The new method exhibits a high tolerance for various functional groups and is scalable using continuous-flow reactors, making it suitable for modifying complex biologically relevant compounds.
Article Abstract
Photocatalytic hydrogen atom transfer is a very powerful strategy for the regioselective C(sp )-H functionalization of organic molecules. Herein, we report on the unprecedented combination of decatungstate hydrogen atom transfer photocatalysis with the oxidative radical-polar crossover concept to access the direct net-oxidative C(sp )-H heteroarylation. The present methodology demonstrates a high functional group tolerance (40 examples) and is scalable when using continuous-flow reactor technology. The developed protocol is also amenable to the late-stage functionalization of biologically relevant molecules such as stanozolol, (-)-ambroxide, podophyllotoxin, and dideoxyribose.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457183 | PMC |
| http://dx.doi.org/10.1002/anie.202104682 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!