Chronic pruritus (itch lasting ≥6 weeks) is a bothersome chief complaint that may present in a broad variety of diseases. Most itch-causing diagnoses fit into 1 of 5 categories (inflammatory, secondary to systemic disease, neuropathic, chronic pruritus of undetermined origin, and psychogenic itch) and this broad differential can be narrowed using key findings in the history and physical. In this article, we discuss which key findings are most pertinent for narrowing this differential and guiding further workup and treatment, as well as how to treat many itchy conditions.
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| http://dx.doi.org/10.1016/j.mcna.2021.04.007 | DOI Listing |
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New Definitions and Subtypes of Chronic Prurigo.
Clin Dermatol
March 2025
Department of Dermatology and Center for Chronic Pruritus, University Hospital Münster, Münster, Germany. Electronic address:
Over the past few years, chronic prurigo, including prurigo nodularis, has become a focal point of considerable research attention, resulting in enhanced insights into this condition. For over two centuries, the term "prurigo" has been utilized in dermatology, often applied loosely to describe a range of pruritic, papulous conditions lacking clear diagnostic criteria. In 2017, the term "chronic prurigo" was introduced, delineating chronic prurigo including prurigo nodularis as a distinct disease entity characterized by chronic pruritus, a characteristic clinical history, and physical signs such as excoriations and the presence of pruriginous lesions.
View Article and Find Full Text PDFBasophil-VAMP7 is A Vital Regulator of Skin Barrier Integrity and Chronic Itch.
J Allergy Clin Immunol
March 2025
School of Biotechnology, Faculty of Science and Health, Dublin City University, Glasnevin, Dublin 9, Ireland. Electronic address:
Background: Atopic Dermatitis (AD) is a multifaceted inflammatory skin disease characterized by chronic itch and Acute Itch Flare (AIF), with basophils playing pivotal roles in both. While VAMP7 (V7) mediates immune responses, its function in basophils remains undefined.
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Department of Pediatric Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN.
Atopic dermatitis (AD)-like graft-versus-host disease (GVHD) is a chronic form of skin GVHD with features that include erythema, xerosis, scaling, and pruritus. Patients often require treatment with systemic immunosuppression and aggressive topical therapies for relief. Long-term effects of chronic immunosuppression are undesirable and alternative therapies are needed.
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Front Vet Sci
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Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
A 12-year-old spayed female Maltese dog had been receiving oclacitinib, a Janus kinase (JAK) inhibitor, for 7 years to manage chronic pruritus due to atopic dermatitis. During this treatment, the dog was diagnosed with primary hypoadrenocorticism and hypothyroidism based on history, physical examination, and hormonal analysis. This case was initially suspected to be polyglandular autoimmune syndrome (PAS) based on long-term treatment of oclacitinib.
View Article and Find Full Text PDFPatient Needs and Treatment Goals in Chronic Atopic Pruritus: Does Eczema Make a Difference?
Acta Derm Venereol
March 2025
Department of Dermatology and Venereology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Chronic pruritus (≥ 6 weeks) is a frequent symptom in atopic diseases, with phenotypes ranging from non-lesional skin to inflammatory diseases like atopic dermatitis. Data on patients' needs and treatment goals depending on the skin phenotype and disease burden are limited. This study aimed to analyse the impact of distinct phenotypes of chronic atopic pruritus on disease burden and treatment goals.
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