AI Article Synopsis
- Tacrolimus (FK506) is an immunosuppressant mainly used to prevent organ rejection in transplant patients but also shows antifungal properties.
- The study demonstrates tacrolimus's strong ability to inhibit the growth of 11 fungi and 3 agricultural oomycetes, indicating potential use in crop protection.
- Molecular docking studies identified a key antifungal enzyme, MurD, as a primary target for tacrolimus, highlighting its significance in developing new agricultural fungicides.
Article Abstract
Tacrolimus (FK506) is an immunosuppressant drug widely used to avoid organ rejection in transplant patients. It has a profound influence on the cellular stress response by interfering with the calmodulin-calcineurin signaling pathway. In this context FK506 also became a valuable antifungal drug in medical care. Here it is shown in vitro that tacrolimus has a potent growth inhibition activity against 11 fungi and 3 oomycetes of agricultural importance. The significance of this finding is discussed with respect to crop protection. The in silico molecular docking to 6 major antifungal enzymes determined UDP-N-acetylmuramoyl-L-alanine: D-glutamate ligase (MurD) as the main target by the best affinity score.
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