AI Article Synopsis
- The study aimed to evaluate the clinical outcomes of different immunosuppressive treatments in patients with severe COVID-19 pneumonia and moderate inflammation.
- A total of 142 patients were divided into three groups based on treatment: methylprednisolone alone, tocilizumab alone, and a combination of both, with a follow-up period of 60 days.
- Results indicated that tocilizumab did not improve clinical outcomes and was associated with a higher ICU admission rate and longer hospital stays, suggesting it should be used cautiously and primarily in clinical trials.
Article Abstract
Aim: To assess clinical outcomes according to the immunosuppressive treatment administered to patients with severe SARS-CoV-2 pneumonia and moderate inflammation.
Methods: A retrospective observational cohort study involving 142 patients with severe COVID-19 pneumonia and moderate inflammation divided into three treatment groups (pulses of methylprednisolone alone [group I], tocilizumab alone [group II] and methylprednisolone plus tocilizumab [group III]). The aim was to assess intergroups differences in the clinical course with a 60-day follow-up and related analytical factors.
Results: 14 patients (9,8%) died: 8 (10%) in group I and 6 (9,5%) in groups II and III. 15 (10,6%) were admitted to ICU: 2 (2,5%) from group I, 4 (28,5%) from group II and 9 (18,4%) from group III. The mean hospital stay was longer in group II and clinical outcome was not associated with treatment.
Conclusions: Tocilizumab seems to be not associated with better clinical outcomes and should be reserved for clinical trial scenario, since its widespread use may result in higher rate of ICU admission and longer mean hospital stay without differences in mortality rate and potentially adverse events.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8142037 | PMC |
| http://dx.doi.org/10.1016/j.medcle.2021.01.004 | DOI Listing |
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