Prognostic Variables of Younger-Aged Cervical Carcinoma Patients: A Retrospective Study.

Purpose: The prevalence of carcinoma of the cervix is increasing in younger women. This study aimed to evaluate the sociodemographic, pathological, and clinical features, prognosis, and treatment of women aged ≤35 years with carcinoma of the cervix (CC).

Methods And Materials: We retrospectively analysed the clinical information of 352 younger women with carcinoma of the cervix aged ≤35 years at the Gynaecological Oncology Department of Zhengzhou University People's Hospital from April 2000 to January 2018. The overall survival was evaluated with the Kaplan-Meier model, and the log-ranked analysis was compared with the univariate analysis to determine prognostic survival-related risk factors. Cox Proportional Hazards analysis was further used in analysing parameters correlated with survival after univariate analysis. A value <0.05 was considered statistically significant. SPSS version 23.0 was used for the data analysis.

Results: The most frequent histopathological type observed in the selected 352 younger women was squamous cell carcinoma (SCC) ( = 221, 62.9%), adenocarcinoma ( = 125, 35.5%), and adenosquamous carcinoma ( = 6, 1.7%). The 5-year overall survival time was 80.5%. The prognostic risk factors discovered through univariate analysis were tumour stage (IA1-IIB vs. IIIA-IVA) (89.2% vs. 35.1%: value = 0.002), histological type (SCC vs. non-SCC) (95.7% vs. 56.2%: value = 0.001), surgical margin (negative vs. positive) (90.9% vs. 41.2%: value = 0.001), and pelvic lymph node metastasis (no vs. yes) (93.4% vs. 39.2%: value = .001). The Cox proportional hazards test demonstrated that lymph node metastases ([HR] = 2.924, 95% CI: 1.432-7.426; =0.014), tumour stage IIIA-IVA ([HR] = 3.765, 95% CI: 1.398-9.765; =0.016), and surgical margin ([HR] = 2.167, 95% CI: 1.987-9.554; =0.019) were independent prognostic risk factors for overall survival in younger women with cervical carcinoma.

Conclusion: In conclusion, the status of lymph node metastases, tumour stage, and surgical margin and the type of histopathology substantially influence the rate of survival.