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| http://dx.doi.org/10.1097/CM9.0000000000001526 | DOI Listing |
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Causal Effects of Valine on Ovarian Cancer: A Bidirectional Mendelian Randomization Analysis.
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Department of Medical Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Background: Ovarian cancer is a lethal female cancer with a rising incidence that is often diagnosed late due to a lack of symptoms, affecting survival and quality of life. Studies suggest that dietary factors, especially the levels of branched-chain amino acids such as valine, may influence its development. While valine is essential for metabolism, its specific role in ovarian cancer remains unclear, necessitating further research.
View Article and Find Full Text PDFInferring transcriptomic dynamics implicated in odor fatty acid accumulation in adipose tissue of Hulun Buir sheep from birth to market.
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December 2024
CAS Key Laboratory of Agroecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan, 410125, China.
This study aimed to investigate the temporal accumulation of odor fatty acids (OFAs) in the dorsal subcutaneous adipose tissue, and uncover their dynamic regulatory metabolic pathways from the transcriptomic perspective in lambs from birth to market. Thirty-two Hulun Buir lambs were selected and randomly assigned to four different sampling stages following their growth trajectories: neonatal (day 1), weaning (day 75), mid-fattening (day 150), and late-fattening (day 180) stages. Results indicated that the contents of three OFAs increased progressively as lambs matured, with the most drastic change occurred at mid-fattening vs.
View Article and Find Full Text PDFThe correlation between Fischer's ratio and the risk of cardiac dysfunction in heart failure patients.
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Department of Cardiovascular Medicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People's Republic of China.
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View Article and Find Full Text PDFInsight into the Structure of the Neutral Amino Acid Transporter BAT2 Enabled the Discovery of Tiagabine as an Inhibitor.
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Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Cracow 30-688, Poland.
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View Article and Find Full Text PDFAcute metabolic decompensation after liver transplant in a patient with maple syrup urine disease.
JIMD Rep
January 2025
Division of Genetics and Genomic Medicine, Department of Pediatrics Washington University School of Medicine St. Louis Missouri USA.
Maple syrup urine disease (MSUD) is an inborn error of metabolism characterized by the accumulation of branched-chain amino acids (leucine, isoleucine, and valine) caused by a defect in the branched-chain alpha-keto acid dehydrogenase complex. Liver transplant is an effective therapy for MSUD, and patients can usually tolerate a regular diet after transplant without symptomatic metabolic decompensation. Most post-transplant patients do not follow a sick-day diet.
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