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Safety of Human USH1C Transgene Expression Following Subretinal Injection in Wild-Type Pigs.
Invest Ophthalmol Vis Sci
January 2025
Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
Purpose: This study aimed to evaluate early-phase safety of subretinal application of AAVanc80.CAG.USH1Ca1 (OT_USH_101) in wild-type (WT) pigs, examining the effects of a vehicle control, low dose, and high dose.
View Article and Find Full Text PDFInvestigating the Post-Disaster Reproductive Health Challenges of Iranian Women: A Systematic Review.
Disaster Med Public Health Prep
January 2025
Health in Emergency and Disaster Research Center, Social Health Research Institute, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Objectives: Disasters pose serious threats to people's health, including reproductive health (RH); therefore, we conducted this study to investigate Iranian women's post-disaster RH challenges.
Methods: This study was conducted as a systematic review, and all published articles until the end of May 2022 were selected by searching in international and domestic scientific databases, including Web of Science, PubMed, Scopus, and Google Scholar, SID, and Magiran. The quality assessment of the studies was done using the Strobe checklist.
Intermittent and increasing intravenous lipopolysaccharide's impact on metabolism, inflammation and production in lactating dairy cows.
J Dairy Sci
January 2025
Department of Animal Science, Iowa State University, Ames, Iowa 50011. Electronic address:
Experimental objectives were to create a chronic inflammatory model to evaluate the effects of persistent immune activation on metabolism, inflammation, and productivity in lactating dairy cows. Twelve lactating Holstein cows (631 ± 16 kg BW; 124 ± 15 DIM) were enrolled in a study with 2 experimental periods (P); during P1 (5 d), cows were fed ad libitum and baseline data were obtained. At the initiation of P2 (7 d), cows were assigned to 1 of 2 treatments: 1) saline-infused and pair-fed (PF; 5 mL intravenously (IV) sterile saline on d 1, 3, and 5; n = 6) or 2) lipopolysaccharide infused and ad libitum-fed (LPS; 0.
View Article and Find Full Text PDFGenome-wide identification and expression analysis of orphan genes in twelve (sub)species.
3 Biotech
February 2025
Centre for Research in Biotechnology for Agriculture (CEBAR), Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Unlabelled: Orphan genes (OGs), also known as lineage-specific genes, are species-specific genes that play a crucial role in species-specific adaptations to various stresses. Although OGs have been identified in several plant species, there is no information on OGs in banana genomes. This study aimed to systematically identify OGs in twelve banana (sub)species using comparative genomics.
View Article and Find Full Text PDFPhase 1 Study of Quercetin, a Natural Antioxidant in Children and Young Adults with Fanconi Anemia (FA).
Blood Adv
January 2025
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.
Fanconi anemia (FA) is a rare inherited disorder characterized by progressive bone marrow failure (BMF) and a predisposition to malignancy. Systemic reactive-oxygen species (ROS) and increased sensitivity of FA hematopoietic progenitors to ROS play a key role in the pathogenesis of BMF. Treatment with antioxidants improve hematopoietic function in Fancc-/- mice.
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