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Background: Deceased donor multiorgan transplants utilizing kidneys (MOTs) can improve outcomes for multiorgan recipients but reduces kidneys for chronic renal failure patients.

Methods: We reviewed the Organ Procurement and Transplantation Network database from 2015 through 2019, for adult deceased donor kidney transplants. Recipients were classified as kidney transplant alone (KTA) (n = 62,252) or MOTs pancreas-kidney, simultaneous pancreas-kidney (n = 3,976), liver-kidney, simultaneous liver-kidney (n = 3,212), heart-kidney, simultaneous heart-kidney (n = 808), and "other"-kidney, simultaneous "other" kidney (n = 73).

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Dual organ transplantation: Pancreas and Liver in the kidney axis.

Curr Opin Nephrol Hypertens

December 2024

Department of Renal Medicine, St. Vincent's University Hospital, University College Dublin, Dublin, Ireland.

Purpose Of Review: This article explores the benefits and challenges of dual organ transplants.

Recent Findings: Simultaneous liver-kidney transplant has become a valuable option for patients with both liver and kidney failure, especially since the introduction of clearer eligibility guidelines in 2017. When done for the appropriate candidate, it can significantly improve survival and quality of life.

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Nonoxidative ethanol metabolites have been reported as ethanol biomarkers in clinical and forensic cases. However, their forensic toxicokinetics are still unclear. The study aimed to simultaneously research the postmortem distribution and dynamic distribution of ethanol and its nonoxidative metabolites in 62 poisoned rabbits.

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Article Synopsis
  • - The study focuses on exertional heat stroke (EHS), which causes central nervous system (CNS) issues and can lead to severe, possibly irreversible organ damage. An optimized model for assessing this damage is essential.
  • - Researchers induced EHS in mice using a controlled environment and assessed organ damage through various tests, finding significant damage to the liver, kidneys, and brain in EHS mice compared to a control group.
  • - The findings highlight an effective animal model for studying EHS that mirrors human clinical traits, allowing for a better understanding of neurological and organ injuries related to this condition.
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