Objective: To assess the mid-term efficacy and safety of anterior urethroplasty using an autologous tissue-engineered oral mucosa graft (MukoCell ).
Methods: The data of 77 patients with anterior urethral strictures undergoing treatment with MukoCell at a tertiary center from June 2016 to May 2019 were analyzed. Patients' characteristics, pre- and postoperative diagnostics, perioperative complications, and follow-up data were obtained. The overall stricture-free survival, outcomes of the different surgical techniques, stricture localizations, stricture length, early complications of the procedure and risk factors of recurrence were assessed.
Results: The median follow-up period was 38 months (interquartile range 31-46). The overall recurrence-free rate of anterior urethroplasty using MukoCell was 68.8%, 24 patients (31.2%) developed a recurrence of the stricture. The stricture recurrences were observed at a median of 7 months (interquartile range 3-13) only in patients with at least one previous surgery or repeated dilatations in their medical history. No oral-urethral adverse events related to the use of MukoCell were observed, except for a urethrocutaneous fistula (1.3%) requiring reoperation.
Conclusions: Anterior one-stage urethroplasty using MukoCell showed in our hands a mid-term success rate of up to 68.8% without significant adverse events after a median follow-up period of 38 months. This procedure might be an alternative option for long-segment urethral reconstruction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/iju.14606 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficacy of the Optilume paclitaxel drug-coated balloon after urethroplasty: short-term results from a multicenter study.
Ther Adv Urol
January 2025
UT Southwestern Department of Urology, Dallas, TX, USA.
Background: The Optilume paclitaxel drug-coated balloon (DCB) is a relatively new-to-market alternative in the management of male anterior urethral stricture disease. The pivotal trial excluded patients with a history of urethroplasty, although these strictures may be amenable to endoscopic management. Therefore, we sought to assess the efficacy of the DCB in the management of recurrent strictures following urethroplasty.
View Article and Find Full Text PDFManagement of a Penile Fracture With Concurrent Urethral Injury: A Case Report.
Cureus
December 2024
Department of Urology, Basaksehir Cam Sakura City Hospital, Istanbul, TUR.
A penile fracture is typically a urological emergency resulting from blunt trauma to the penis, particularly during sexual activity, and it is rarely associated with urethral injury. A 52-year-old male patient presented to our emergency department with complaints of penile swelling and bruising following sexual intercourse. Assessment of the patient indicated the presence of both penile fracture and anterior urethral injury, and simultaneous repairs were performed.
View Article and Find Full Text PDFSurgical and patient-reported outcomes of staged urethroplasty for anterior urethral strictures: A comprehensive analysis.
Int J Urol
January 2025
Department of Urology, National Defense Medical College, Saitama, Japan.
Objectives: To evaluate the efficacy of staged urethroplasty for complex anterior urethral strictures from both surgical and patient-reported outcome perspectives.
Methods: This retrospective study included 100 patients who underwent staged urethroplasty for anterior urethral strictures between May 2011 and June 2023. Anatomical success was defined as the ability to pass cystourethroscopy without resistance and the patient's ability to void without additional interventions.
Cosmetic complications after anterior urethral surgery: a scoping review and photo collection.
Actas Urol Esp (Engl Ed)
January 2025
Unidad de Andrología y Cirugía Reconstructiva, Hospital Universitario Marqués de Valdecilla, Facultad de Medicina, Universidad de Cantabria, Instituto de Investigación Valdecilla (IDIVAL), Santander, Spain. Electronic address:
Introduction: Anterior urethroplasty is the gold standard for treating complex urethral strictures, primarily focusing on restoring urinary function. However, aesthetic complications, including penile curvature, scarring, and meatal deformities, can impact patient satisfaction, self-image, and quality of life. Despite their significance, cosmetic outcomes are underreported in the literature, affecting patient counseling and surgical planning.
View Article and Find Full Text PDFDevelopment and Validation of the Length, Segment, and Etiology Anterior Urethral Stricture Disease Staging System Using Longitudinal Urethroplasty Outcomes Data From the Trauma and Urologic Reconstruction Network of Surgeons.
J Urol
December 2024
Department of Urology, New York University, New York, New York.
Purpose: The purpose of this study was to create and validate an anterior urethral stricture disease (aUSD) staging system based on the previously validated Length (L), Urethral Segment (S), and Etiology (E, LSE) classification system.
Materials And Methods: The Trauma and Urologic Reconstruction Network of Surgeons (TURNS) prospective database was used to create and validate the staging system. A novel Urethroplasty Triad Score was created to aid in ranking the stagings into stricture severity based on (1) functional outcomes, (2) location of urethral meatus (eg, orthotopic, perineal), and (3) number of surgeries required for repair.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!