AI Article Synopsis
- HFpEF and CKD represent a high-risk combination that leads to serious health issues and poor outcomes.
- The interaction of various inflammatory conditions, hemodynamic factors, and other mechanisms contributes to kidney dysfunction in HFpEF patients.
- Currently, there are few effective treatments for HFpEF, so research tailored to its specific characteristics and underlying causes could help develop better targeted therapies.
Article Abstract
Heart failure with preserved ejection fraction (HFpEF) and chronic kidney disease (CKD) constitute a high-risk phenotype with significant morbidity and mortality and poor prognosis. Multiple proinflammatory comorbid conditions influence the pathogenesis of HFpEF and CKD. Renal dysfunction in HFpEF is a consequence of the complex interplay between hemodynamic factors, systemic congestion, inflammation, endothelial dysfunction, and neurohormonal mechanisms. In contrast to heart failure with reduced ejection fraction, there is a dearth of effective targeted therapies for HFpEF. Tailoring study design toward the different phenotypes and delving into their pathophysiology may be fruitful in development of effective phenotype-specific targeted pharmaceutical therapies.
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| http://dx.doi.org/10.1016/j.hfc.2021.03.005 | DOI Listing |
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