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| http://dx.doi.org/10.1016/j.jaad.2021.05.020 | DOI Listing |
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Changes in miRNA Pattern Expression Associated With COVID-19 Severity.
In Vivo
December 2024
Laboratorio de Biología Molecular, Laboratorio Estatal de Salud Pública del Estado de México, Toluca de Lerdo, Mexico
Background/aim: Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 infection, manifests a wide range of clinical symptoms ranging from mild to moderate and severe. Host-related factors influence the course of SARS-CoV-2 infection; for instance, the expression of host microRNAs (miRNAs) could influence the progression and complications of COVID-19. This study aimed to determine the expression pattern of endogenous miRNAs in 80 severe COVID-19 patients compared to a group of healthy individuals.
View Article and Find Full Text PDFImmunogenicity and safety of SARS-CoV-2 recombinant protein vaccine (CHO cell) LYB001 as a heterologous booster following two- or three-dose inactivated COVID-19 vaccine in adults aged ≥18 years: interim results of a randomized, active-controlled, double-blinded, phase 3 trial.
Expert Rev Vaccines
December 2024
Guangzhou Patronus Biotech Co, Ltd, Guangzhou, China.
Background: LYB001 is a recombinant protein COVID-19 vaccine displaying a receptor-binding domain (RBD) in a highly immunogenic array on virus-like particles (VLPs). This study assessed the immunogenicity and safety of LYB001 as a booster.
Research Design And Methods: In this randomized, active-controlled, double-blinded, phase 3 trial, participants aged ≥18 years received a booster with LYB001 or ZF2001 (Recombinant COVID-19 Vaccine).
Energetic activity for depression in young people aged 13-17 years: the READY feasibility RCT.
Health Technol Assess
December 2024
Centre for Research in Public Health and Community Care, University of Hertfordshire, Hatfield, UK.
Article Synopsis
- The study aims to evaluate the feasibility of an exercise intervention for young people aged 13-17 with mild to moderate depression, comparing high-intensity exercise, low-intensity exercise, and social activities.
- Participants were recruited through mental health services and schools, with the intervention delivered over 12 weeks by trained professionals.
- Results showed a 71.4% retention rate and over 67% attendance, although only 14 participants were randomized from the initial referrals, indicating challenges in recruitment.
Cost-effectiveness of outpatient COVID-19 antiviral treatment with Nirmatrelvir/Ritonavir versus usual care in Swedish patients with various risk factors.
J Med Econ
December 2024
Pfizer Inc., Tadworth, Surrey, United Kingdom.
Aims: Nirmatrelvir/ritonavir (NMV/r) is an orally administered antiviral indicated for the outpatient treatment of adult patients with mild-to-moderate COVID-19 at high risk for disease progression to severe illness. We estimated the cost-effectiveness of NMV/r versus best supportive care for 54 patient cohorts, specified according to age, vaccination status and comorbidity burden.
Materials And Methods: A previously published and validated cost-effectiveness model was utilized and adapted to the Swedish setting.
Relationships between Fetal and Neonatal Outcomes and Spectrum of COVID-19 Disease in Pregnant Women.
Tanaffos
January 2024
Department of Epidemiology, Faculty of Medical Sciences, Qom University of Medical Sciences, Qom, Iran.
Background: Due to the high prevalence of COVID-19 and the prevention and control of adverse fetal and neonatal outcomes in pregnant women, including vertical transmission, this study was performed to describe the fetal and neonatal outcomes of pregnancy with a spectrum of COVID-19 disease during pregnancy in Iran.
Materials And Methods: In this cross-sectional study, we analyzed the medical records of 258 pregnant women admitted to the Forghani Hospital, Qom, Iran, from 18 February 2020, to May 10, 2021. PCR-RT or respiratory compromise in the presence of marked radiographic changes of COVID-19 in the lungs, or both COVID-19 disease confirmed COVID-19 disease.
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