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The allele corresponds to a very large haploblock likely explaining its massive effect for HIV-1 elite control.
Front Immunol
December 2023
Laboratoire Génomique, Bioinformatique, et Chimie Moléculaire, EA7528, Conservatoire National des Arts et Métiers, HESAM Université, Paris, France.
Introduction: We have reanalyzed the genomic data of the International Collaboration for the Genomics of HIV (ICGH), centering on HIV-1 Elite Controllers.
Methods: We performed a genome-wide Association Study comparing 543 HIV Elite Controllers with 3,272 uninfected controls of European descent. Using the latest database for imputation, we analyzed 35,552 Single Nucleotide Polymorphisms (SNPs) within the Major Histocompatibility Complex () region.
Inactivation of Attenuated Pancreatic Tumorigenesis in Mice.
Cancer Res Commun
December 2022
Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.
Unlabelled: Expression of the Notch family of receptors is often upregulated in pancreatic ductal adenocarcinoma (PDAC). In this study, we focused on Notch4, which had not been investigated in PDAC. We generated KC (), N4 KC (), PKC (), and N4 PKC () genetically engineered mouse models (GEMM).
View Article and Find Full Text PDFCellular heterogeneity and transcriptomic profiles during intrahepatic cholangiocarcinoma initiation and progression.
Hepatology
November 2022
School of Automation Science and Engineering, Faculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Background And Aims: Intrahepatic cholangiocarcinoma (ICC) is not fully investigated, and how stromal cells contribute to ICC formation is poorly understood. We aimed to uncover ICC origin, cellular heterogeneity, and critical modulators during ICC initiation/progression, and to decipher how fibroblast and endothelial cells in the stromal compartment favor ICC progression.
Approach And Results: We performed single-cell RNA sequencing (scRNA-seq) using AKT/Notch intracellular domain-induced mouse ICC tissues at early, middle, and late stages.
Notch4, uncovering an immunomodulator in allergic asthma.
Allergy
December 2021
Division of Respirology, Department of Medicine, McMaster University, Hamilton & Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, ON, Canada.
Unsuspected Associations of Variants within the Genes NOTCH4 and STEAP2-AS1 Uncovered by a GWAS in Endemic Pemphigus Foliaceus.
J Invest Dermatol
November 2021
Programa de Pós-Graduação em Genética, Universidade Federal do Paraná, Curitiba, Brazil. Electronic address:
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