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Push-pull effects of basal ganglia network in Parkinson's disease inferred by functional MRI.
NPJ Parkinsons Dis
November 2024
School of Electrical and Information Engineering, Tianjin University, Tianjin, China.
Deep brain stimulation (DBS) can ameliorate motor symptoms in Parkinson's disease (PD), but its mechanism remains unclear. This work constructs a multi-scale brain model using the fMRI data from 27 PD patients with subthalamic DBS and 30 healthy controls. The model fits microscopic coupling parameters in the cortico-basal ganglia-thalamic neural loop to match individual connectivity, finding the "push-pull" effect of basal ganglia network.
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- In the study, participants showed that VS connectivity is closely tied to the Salience network, particularly linking to areas like the anterior insula and the dorsolateral prefrontal cortex (DLPFC).
- The findings imply that the DLPFC could be a promising target for treating major depressive disorder due to its strong connection with the VS, opening avenues for personalized treatment approaches.
Connecting the dots - A systematic review on coherence analysis in dystonia.
Neurobiol Dis
October 2024
Departments of Neurology, University Medical Center Groningen, University of Groningen, the Netherlands; Expertise Center Movement Disorders Groningen, University Medical Center Groningen. University of Groningen, the Netherlands. Electronic address:
Background: Increased 4-12 Hz oscillatory activity in the cortico-basal ganglia-thalamo-cortical (CBGTC) loop is reported in dystonia. Coherence analysis is a measure of linear coupling between two signals, revealing oscillatory activity drives that are common across motor units. By performing coherence analysis, activity of the CBGTC-loop can be measured with modalities like local field potentials (LFPs), electromyography (EMG), and electro-encephalography (EEG).
View Article and Find Full Text PDFPhase Delays between Mouse Globus Pallidus Neurons Entrained by Common Oscillatory Drive Arise from Their Intrinsic Properties, Not Their Coupling.
eNeuro
May 2024
Department of Neuroscience, Developmental and Regenerative Biology, University of Texas at San Antonio, San Antonio, Texas 78249
A hallmark of Parkinson's disease is the appearance of correlated oscillatory discharge throughout the cortico-basal ganglia (BG) circuits. In the primate globus pallidus (GP), where the discharge of GP neurons is normally uncorrelated, pairs of GP neurons exhibit oscillatory spike correlations with a broad distribution of pairwise phase delays in experimental parkinsonism. The transition to oscillatory correlations is thought to indicate the collapse of the normally segregated information channels traversing the BG.
View Article and Find Full Text PDFExamining resting state functional connectivity and frequency power analysis in adults who stutter compared to adults who do not stutter.
Front Hum Neurosci
February 2024
Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Introduction: Stuttering is a speech disorder characterized by impaired connections between brain regions involved in speech production. This study aimed to investigate functional connectivity and frequency power during rest in adults who stutter (AWS) compared to fluent adults (AWNS) in the dorsolateral prefrontal cortex (DLPFC), dorsolateral frontal cortex (DLFC), supplementary motor area (SMA), motor speech, angular gyrus (AG), and inferior temporal gyrus (ITG).
Materials And Methods: Fifteen AWS (3 females, 12 males) and fifteen age- and sex-matched AWNS (3 females, 12 males) participated in this study.
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