The human health risks caused by heavy metal contamination (As, Cd, Cr, Cu, Hg, Pb, Ni, and Zn) in the surface water of the Houjing River, the most contaminated river in southern Taiwan, were assessed in this study. Firstly, heavy metal contamination was evaluated by the contamination factors (CF) and the metal indexes (MI). Secondly, the human health risks due to heavy metal contamination were simulated using the Adaptive Risk Assessments Modeling System (ARAMS) through three scenarios; fish ingestion, dermal water contact, and incidental water ingestion during swimming. The hazard quotient (HQ) and the hazard index (HI) were used to evaluate non-carcinogenic risks, while carcinogenic risks were estimated by the lifetime cancer incidence risk index (CR) and the cumulative cancer risk (CCR). The results showed that the synergistic contamination of heavy metals in the surface water was severe (MI = 12.4), with the highest contribution from Cu, Ni, and Pb. Copper had the highest non-carcinogenic risk at the "adverse effect" level, while Ni and Cr had the highest carcinogenic risk at an "unacceptable" level. In addition, the cumulative risks of fish ingestion (HI = 6.75 and CCR = 1.25E-03) were significantly higher than those of the swimming scenarios (HI = 1.94E-03 and CCR = 9.32E-08). The results from this study will be beneficial for immediate and future contamination control measures and human health management plans for this study area. This study has also demonstrated the effectiveness of using ARAMS in human health risk assessment.
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http://dx.doi.org/10.1016/j.envpol.2021.117414 | DOI Listing |
In the context of Chinese clinical texts, this paper aims to propose a deep learning algorithm based on Bidirectional Encoder Representation from Transformers (BERT) to identify privacy information and to verify the feasibility of our method for privacy protection in the Chinese clinical context. We collected and double-annotated 33,017 discharge summaries from 151 medical institutions on a municipal regional health information platform, developed a BERT-based Bidirectional Long Short-Term Memory Model (BiLSTM) and Conditional Random Field (CRF) model, and tested the performance of privacy identification on the dataset. To explore the performance of different substructures of the neural network, we created five additional baseline models and evaluated the impact of different models on performance.
View Article and Find Full Text PDFSyst Biol Reprod Med
December 2025
Department of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
MicroRNAs (miRNAs) have acquired an increased recognition to unravel the complex molecular mechanisms underlying Diminished Ovarian Reserve (DOR), one of the main responsible for infertility. To investigate the impact of miRNA profiles in granulosa cells and follicular fluid, crucial players in follicle development, this study employed a computational network theory approach to reconstruct potential pathways regulated by miRNAs in granulosa cells and follicular fluid of women suffering from DOR. Available data from published research were collected to create the FGC_MiRNome_MC, a representation of miRNA target genes and their interactions.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
January 2025
Department of Neurology, Jinshan Hospital, Fudan University, 201508 Shanghai, China.
Background: Neuronal cholesterol deficiency may contribute to the synaptopathy observed in Alzheimer's disease (AD). However, the underlying mechanisms remain poorly understood. Intact synaptic vesicle (SV) mobility is crucial for normal synaptic function, whereas disrupted SV mobility can trigger the synaptopathy associated with AD.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
January 2025
Department of Cardiothoracic Surgery, The Affiliated Jiangyin Hospital of Nantong University, 214400 Jiangyin, Jiangsu, China.
Background: This study investigates the role of small ubiquitin-like modifier (SUMO)-specific peptidase 5 (SENP5), a key regulator of SUMOylation, in esophageal squamous cell carcinoma (ESCC), a lethal disease, and its underlying molecular mechanisms.
Methods: Differentially expressed genes between ESCC mouse oesophageal cancer tissues and normal tissues were analysed via RNA-seq; among them, SENP5 expression was upregulated, and this gene was selected for further analysis. Immunohistochemistry and western blotting were then used to validate the increased protein level of SENP5 in both mouse and human ESCC samples.
Front Biosci (Landmark Ed)
January 2025
Division of Biochemistry and Molecular Biology, Federal State Budgetary Educational Institution of Higher Education "Siberian State Medical University" of the Ministry of Health of Russia, 634050 Tomsk, Russia.
Background: Over the past five years, the pregnancy rate in assisted reproductive technology (ART) programs in Russia has remained relatively stable. The aim of this study was to assess the distribution of monocyte and macrophage subsets in the blood and follicular fluid of infertile women undergoing assisted reproductive technology.
Methods: The study involved 45 women with a mean age of 35 ± 4.
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