Purpose: Modifying, translating to Arabic, trans-culturally adapting, and testing the psychometric properties of colorectal cancer knowledge perception screening survey (CRCKPSS) to fit with Arabic culture to measure Jordanian average risk population's health beliefs about colorectal cancer (CRC).
Methods: A methodological cross-sectional design was employed to recruit a convenience sample of 460 average-risk Jordanian adults aged 50-75 years from the outpatient departments (OPDs) of two governmental hospitals in Jordan. The study was conducted in three phases: (a) Minimal modification of the CRCKPSS was undertaken. (b) Translation and transcultural adaptation of the modified version from English to Arabic were undertaken. (c) Validation of the trans-culturally modified Arabic version was performed.
Results: Construct validity of the final trans-culturally modified Arabic version was evaluated by exploratory and confirmatory factor analysis, which yielded five factors. The total variance explained by all extracted factors was 83.4%. Cronbach's alpha was applied separately for all five subscales and ranged between 0.94 and 0.98, indicating that the adapted version items have distinguishing consistency.
Conclusions: Examining communities' health beliefs regarding CRC is an important issue and requires a culturally valid and reliable scale. The modified Arabic version exhibited acceptable content, construct, convergent, and discriminant validity when used with the Jordanian average-risk population. Nurses and other health professionals can use it to assess beliefs about CRC and screening practices accurately. Moreover, the scale may be beneficial to other Arab countries, considering the diverse dialects within the Arab world.
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http://dx.doi.org/10.31557/APJCP.2021.22.5.1537 | DOI Listing |
Cancer
March 2025
Department of Oncology, Karmanos Cancer Institute at Wayne State University, Detroit, Michigan, USA.
Background: Prior studies of participants with breast and other obesity-associated cancers in the Women's Health Initiative (WHI) showed worse mortality and cardiovascular disease (CVD) outcomes for individuals with a higher number of cardiometabolic risk factors at study entry. The purpose of this analysis is to compare the relationship between cardiometabolic abnormalities and mortality among women with and without cancer in the WHI.
Methods: Women with one of five early-stage obesity-associated cancers (breast, colorectal, endometrial, ovarian, and non-Hodgkin lymphoma) and controls without any new or prior history of cancer were selected from the WHI-Life and Longevity after Cancer ancillary study.
J Gastrointest Cancer
March 2025
Department of Interventional Therapy, National Cancer Centre/National Clinical Research Centre for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Objective: To compare early recurrence patterns, safety, survival and investigate the clinical risk factors of early recurrence (ER) after liver resection or thermal ablation (TA) for patients with colorectal liver metastases (CRLM) with number ≤ 5 and largest diameter ≤ 3 cm.
Materials And Methods: This retrospective study included patients with CRLM who underwent liver resection or TA between January 2016 and December 2021 at two hospitals in China. The Kaplan-Meier method and log-rank test were used to assess recurrence-free survival (RFS) and overall survival (OS).
Cancer Chemother Pharmacol
March 2025
Medical Oncology, Department of Clinical and Molecular Sciences, University Politecnica delle Marche, Ancona, 60126, Italy.
In recent years, assessing dihydropyrimidine dehydrogenase (DPD) activity has become crucial for cancer patients undergoing 5-fluorouracil (5FU)-based chemotherapy due to the life-threatening toxicity associated with reduced DPD function. The methods for evaluating DPD activity have evolved, with the analysis of DPYD polymorphisms in blood samples becoming the preferred approach. As the indications for liver transplantation are increasing-particularly due to a rise in cases of cholangiocarcinoma (CCA) and non-resectable colorectal liver metastasis-more cancer patients with a history of liver transplantation may experience disease relapse.
View Article and Find Full Text PDFInt J Colorectal Dis
March 2025
The Second Xiangya Hospital, Central South University, Changsha, China.
J Biomater Appl
March 2025
Department of Chemistry, School of Pharmacy, North Sichuan Medical College, Nanchong, China.
Colorectal cancer is the fourth leading cause of cancer-related deaths worldwide. Capecitabine is a chemotherapeutic agent commonly used for the treatment of colon cancer. To realize local sustained release, promote efficient local intracellular transport, and mitigate the systemic toxic effects of capecitabine, a capecitabine prodrug, capecitabine-poly (p-dioxanone) (Cap-PPDO), was successfully synthesized.
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