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Alzheimers Dement
December 2024
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: Characterizing stress can inform our understanding of direct and indirect pathways impacting mental and physical health outcomes, including age-related cognitive decline. Chronic stress has been strongly associated with increased risk for cognitive decline, and hair cortisol concentration (HCC) has emerged as a viable neuroendocrine biomarker for its quantification. Cognitive appraisal of stress (CAS) provides key insight into the cognitive framework for responding to a given stressor.
View Article and Find Full Text PDFMultiple cutaneous mast cell tumors displaying epitheliotropism in a male cat.
Can Vet J
January 2025
Department of Small Animal Clinical Sciences (Cormillot, Weissman, MacDonald-Dickinson) and Department of Veterinary Pathology (Dickinson), Western College of Veterinary MeDicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.
A 16-year-old castrated male domestic medium-hair cat was referred for examination of multiple cutaneous mast cell tumors displaying epitheliotropism. Staging tests were negative for distant metastasis. Toceranib phosphate therapy was initiated.
View Article and Find Full Text PDFis required to maintain supporting cell identity and vestibular function during maturation of the mammalian balance organs.
J Neurosci
January 2025
Flaum Eye Institute, Department of Ophthalmology, University of Rochester Medical Center, Rochester, New York, 14642, USA;
The inner ear houses both hearing and balance sensory modalities. The hearing and balance organs consist of similar cell types, including sensory hair cells and associated supporting cells. Previously we showed that is required for maintaining supporting cell survival during cochlear maturation.
View Article and Find Full Text PDFMyosin XVA isoforms participate in the mechanotransduction-dependent remodeling of the actin cytoskeleton in auditory stereocilia.
Front Neurol
December 2024
Department of Physiology, University of Kentucky, Lexington, KY, United States.
Auditory hair cells form precise and sensitive staircase-like actin protrusions known as stereocilia. These specialized microvilli detect deflections induced by sound through the activation of mechano-electrical transduction (MET) channels located at their tips. At rest, a small MET channel current results in a constant calcium influx which regulates the morphology of the actin cytoskeleton in the shorter 'transducing' stereocilia.
View Article and Find Full Text PDFEvaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular-Targeting for Androgenic Alopecia Topical Treatment.
Pharmaceutics
November 2024
Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia (UnB), Brasília 70910-900, DF, Brazil.
Although androgenic alopecia is the most prevalent among non-cicatricial alopecia, it still lacks an effective and safe treatment. Dutasteride (DUT) shows promising results in hair regrowth; however, oral DUT intake causes serious sexual adverse events. Hence, we produced liposomes with different bilayer structures and evaluated the capability of such systems in increasing DUT accumulation in the hair follicles.
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