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Prophylaxis in von Willebrand disease with von Willebrand factor concentrate and nonfactor therapies.
Res Pract Thromb Haemost
November 2024
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.
This manuscript summarizes the current status of prophylaxis and novel potential therapies to prevent bleeding in patients with von Willebrand disease (VWD). VWD is the most common inherited bleeding disorder, which is associated mainly with mucocutaneous bleeding and bleeding during surgical and dental interventions. More severely affected VWD patients, mostly those with type 2 and type 3, can also suffer from joint, muscle, and gastrointestinal bleeds.
View Article and Find Full Text PDFGuidelines and guidance: what is the path forward for the ISTH?
J Thromb Haemost
November 2024
Division of General Internal Medicine, Department of Medicine, McMaster University, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada; Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada. Electronic address:
Low vitamin C status and hypermobility-related disorders in patients with bleeding disorder of unknown cause.
Haemophilia
November 2024
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Article Synopsis
- BDUC is a difficult-to-diagnose bleeding disorder mostly affecting women, and this study explores its connection to hypermobility disorders and vitamin C levels.
- The study included 60 patients with BDUC, finding a significant prevalence of hypermobility traits and hyperextensible skin compared to healthy controls, along with some diagnosed with hypermobile Ehlers-Danlos syndrome.
- Results indicated that while patients had adequate vitamin C levels, they were still lower than those in healthy controls, suggesting a potential area for further research on vitamin C supplementation for BDUC patients.
Erratum to 'Illustrated State-of-the-Art Capsules of the ISTH 2024 Congress' [Research and Practice in Thrombosis and Haemostasis Volume 8, Issue 4, May 2024, 102432].
Res Pract Thromb Haemost
July 2024
Servicio de Hematología, Hospital Universitario Morales Meseguer, Centro Regional de Hemodonación, Universidad de Murcia, IMIB-Arrixaca, CIBERER-U765, Murcia, Spain.
[This corrects the article DOI: 10.1016/j.rpth.
View Article and Find Full Text PDFSyndemics in women's health: poverty, social exclusion, and clustering of thrombotic and hemostasis disorders.
Res Pract Thromb Haemost
July 2024
Haematology, Mater Misericordiae University Hospital, Dublin, Ireland.
A State of the Art lecture titled "Syndemics in Women's Health: Poverty, Social Exclusion and Clustering of Thrombotic and Haemostasis Disorders" was presented at the International Society on Thrombosis and Haemostasis (ISTH) Congress in 2023. Syndemics are characterized by the clustering of specific health conditions in vulnerable populations. These populations become vulnerable as a result of large-scale social, political, and economic factors that influence social determinants of health and increase susceptibility to disease.
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