AI Article Synopsis
- RIOK2 is a kinase linked to various human cancers, like non-small cell lung cancer and glioblastoma, but lacks effective chemical probes for research.
- The study details the creation of naphthyl-pyridine compounds that show better cellular activity and selectivity for RIOK2.
- Although these compounds are not true probes for RIOK2, they serve as the best available tools to investigate the kinase's role in cancer biology.
Article Abstract
RIOK2 is an understudied kinase associated with a variety of human cancers including non-small cell lung cancer and glioblastoma. No potent, selective, and cell-active chemical probe currently exists for RIOK2. Such a reagent would expedite re-search into the biological functions of RIOK2 and validate it as a therapeutic target. Herein, we describe the synthesis of naphthyl-pyridine based compounds that have improved cellular activity while maintaining selectivity for RIOK2. While our compounds do not represent RIOK2 chemical probes, they are the best available tool molecules to begin to characterize RIOK2 function .
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130602 | PMC |
| http://dx.doi.org/10.1039/d0md00292e | DOI Listing |
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