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Infliximab therapy provides beneficial effects for choroidal thickness increase in patients with active ankylosing spondylitis: A possible mechanism mediating the suppressing of uveitis attacks. | LitMetric

AI Article Synopsis

  • The study assesses choroidal thickness in patients with ankylosing spondylitis (AS) using optical coherence tomography (OCT) to determine if infliximab therapy can reverse eye abnormalities associated with the condition.
  • Thirty-one AS patients and 24 healthy controls were examined for retinal nerve fiber layer thickness, ganglion cell complex, and choroidal thickness, both before starting infliximab and six months later.
  • Results showed that active AS patients had higher choroidal thickness initially, but it significantly decreased after infliximab treatment, indicating the therapy's potential effectiveness in reducing eye-related complications in AS.

Article Abstract

Objectives: This study aims to quantitatively assess the profile of the choroidal thickness (ChT) in patients with ankylosing spondylitis (AS) using optical coherence tomography (OCT), and to examine whether the posterior eye segment abnormalities in active AS patients are reversible by infliximab therapy.

Patients And Methods: October 2014 and March 2016 Thirty-one patients with AS (22 males, 9 females; mean age 39.6±12.3 years; range, 22 to 68 years) and 24 healthy controls (16 males, 8 females; mean age 40.8±8.9 years; range, 35 to 61 years) were enrolled. Patients' clinical and demographic characteristics were recorded. Using OCT, we performed retinal nerve fiber layer (RNFL) thickness, ganglion cell complex, and ChT measurements in AS patients before and six months after the initiation of infliximab therapy, and in healthy controls.

Results: At baseline, patients with AS had higher ChT (mean±standard deviation: 347.5±114.4 μm) compared to healthy controls (322.1±62.8 μm), although this did not reach statistical significance level (p=0.283). At six months after the first measurement, the mean ChT was significantly decreased (under infliximab therapy: 326.5±99.7 μm vs. before: 347.5±114.4 μm, p=0.018) in AS group, while no significant change was observed in the control group (p=0.102). RNFL thickness in the AS group was significantly decreased after six months of treatment with infliximab (p=0.008).

Conclusion: By evaluating the posterior eye segment of patients with AS using OCT, this study has demonstrated that active AS patients had higher ChT. The significant reduction in this ChT after infliximab therapy may be mediating the established effective suppressing action of infliximab on uveitis attacks.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8140873PMC
http://dx.doi.org/10.46497/ArchRheumatol.2021.7806DOI Listing

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