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Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection, with resistance to antimalarial drugs, including artemisinin-based combination therapies(ACTs), posing a significant threat. CD4+ naive cells expressing CCR7 are known to play a protective role, as they readily migrate to secondary lymphoid tissues activated by CCL19 chemokines. In an effort to address this challenge, we investigated the impact of Annona muricata, an herbaceous and immunomodulatory plant, on CCL19 concentration.
View Article and Find Full Text PDFEvaluation of the merit of ethanolic extract of as an anti-cancer agent in human colon cancer cell lines (HCT-116).
F1000Res
January 2025
Department of Biochemistry, Kastubra Medical College Manipal, Maniapl Academy of Higher Education, Manipal, Karnataka, India.
Background: Colon cancer is the third most common cancer type worldwide. Novel alternative therapeutic anti-cancer drugs against colon cancer with less toxicity are to be explored . This study was aimed to explore the anti-proliferative and anti-migratory activity of various fractions of ethanolic leaf extract on human colon cancer cell lines (HCT-116) and to explore the potential molecular targets from the most potent plant extract fraction.
View Article and Find Full Text PDFExploring the phytoremediation potential of plant species in soils impacted by gold mining in Northern Colombia.
Environ Sci Pollut Res Int
January 2025
Environmental Chemistry Department, Institute of Environmental Assessment and Water Research, IDAEA-CSIC, 08034, Barcelona, Spain.
Contamination of soils with toxic metals poses significant threats to human health and ecosystems. Plant-based remediation strategies can play a vital role in mitigating these risks, and the use of plants as a remediation strategy can help reduce these risks. In this study, we investigate the remediation potential of native plants in accumulating and translocating metal(loid)s at a Colombian site impacted by gold mining.
View Article and Find Full Text PDFCharacterization and enhanced antibiofilm activity of extract in combination with fluconazole against .
Drug Target Insights
January 2025
Department of Pharmacology, University of Free State, Bloemfontein - South Africa.
Introduction: biofilm formation is a significant contributor to antifungal resistance, necessitating new treatment strategies. Lin., a traditional herbal remedy, has shown promise in combating microbial infections.
View Article and Find Full Text PDFComparative phytochemical and pharmacological analysis of two cultivars of Annona squamosa L. cultivated in Egypt.
NPJ Sci Food
January 2025
Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Article Synopsis
- The study compared two cultivars of Annona squamosa (Abdelrazik and Balady) in terms of their chemical profiles and cytotoxic effects against cancer cell lines.
- Annona A. showed higher acetogenin content and stronger cytotoxic activity, while Annona B. had more carbohydrates but less magnesium.
- DNA barcoding identified effective methods for species and cultivar differentiation, suggesting that Annona squamosa cultivars might be useful in developing cancer therapies and immune boosters.
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