The emerging role of RNA N6-methyladenosine methylation in breast cancer.

Biomark Res

Department of Medical Oncology, National Cancer Centre/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Beijing, 100021, China.

Published: May 2021

N6-methyladenosine (m6A) modification is the most prevalent internal mRNA modification and is involved in many biological processes in eukaryotes. Accumulating evidence has demonstrated that m6A may play either a promoting or suppressing role in breast cancer, including in tumorigenesis, metastasis and angiogenesis. In this review, we summarize the latest research progress on the biological function and prognostic value of m6A modification in breast cancer, as well as potential related therapeutic strategies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161983PMC
http://dx.doi.org/10.1186/s40364-021-00295-8DOI Listing

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