Some studies have reported results from the use of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) to treat osteoarthritis (OA). To evaluate the efficacy of MSC-EVs as a treatment for OA. Databases were searched using the terms 'mesenchymal stem cells', 'osteoarthritis' and 'extracellular vesicles.' Studies performed in animal models utilizing MSC-EVs to treat OA that described the macroscopic evaluation or histological evaluation were included. The quality of the studies was examined using the CAMARADES quality checklist. MSC-EVs were superior to the placebo in the macroscopic evaluation and histological evaluation. MSC-EVs were more effective in the early stage of OA and once a week was better than multiple times a week. The included studies were highly heterogeneous. MSC-EVs may improve the results of macroscopic and histological evaluations of OA.
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| http://dx.doi.org/10.2217/nnm-2021-0047 | DOI Listing |
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