AI Article Synopsis
- Stereotactic neurosurgery is a precise technique that uses image guidance to deliver treatments directly to specific brain areas for various purposes, including tumor therapy and drug delivery.
- The article focuses on convection-enhanced delivery as a method to transport therapeutic agents into the brain, discussing both research progress and clinical challenges in this field.
- Key biophysical properties of how drugs move in the brain's extracellular space are outlined, emphasizing their importance for improving drug delivery models and techniques in stereotactic neurosurgery.
Article Abstract
Stereotactic neurosurgery involves a targeted intervention based on congruence of image guidance to a reference fiducial system. This discipline has widespread applications in radiosurgery, tumor therapy, drug delivery, functional lesioning, and neuromodulation. In this article, we focused on convection-enhanced delivery to deliver therapeutic agents to the brain addressing areas of research and clinical development. We performed a robust literature review of all relevant articles highlighting current efforts and challenges of making this delivery technique more widely understood. We further described key biophysical properties of molecular transport in the extracellular space that may impact the efficacy and control of drug delivery using stereotactic methods. Understanding these principles is critical for further refinement of predictive models that can inform advances in stereotactic techniques for convection-enhanced delivery of therapeutic agents to the brain.
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| http://dx.doi.org/10.1016/j.wneu.2021.05.050 | DOI Listing |
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