AI Article Synopsis
- The first US case of SARS-CoV-2 was identified on January 20, 2020, but some studies suggest it may have existed in the country as early as December 2019.
- A study in the greater Seattle area aimed to determine the prevalence of SARS-CoV-2 antibodies among adults from October 2019 to early April 2020.
- Results showed no antibodies were present from October 2019 to March 2020, with a prevalence of only 1.2% detected by late March and early April, indicating limited COVID-19 circulation in that period.
Article Abstract
Background: The first US case of SARS-CoV-2 infection was detected on January 20, 2020. However, some serology studies suggest SARS-CoV-2 may have been present in the United States prior to that, as early as December 2019. The extent of domestic COVID-19 detection prior to 2020 has not been well-characterized.
Objectives: To estimate the prevalence of SARS-CoV-2 antibody among healthcare users in the greater Seattle, Washington area from October 2019 through early April 2020.
Study Design: We tested residual samples from 766 Seattle-area adults for SARS-CoV-2 antibodies utilizing an ELISA against prefusion-stabilized Spike (S) protein.
Results: No antibody-positive samples were found between October 2, 2019 and March 13, 2020. Prevalence rose to 1.2% in late March and early April 2020.
Conclusions: The absence of SARS-CoV-2 antibody-positive samples in October 2019 through mid-March, 2020, provides evidence against widespread circulation of COVID-19 among healthcare users in the Seattle area during that time. A small proportion of this metropolitan-area cohort had been infected with SARS-CoV-2 by spring of 2020.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8158900 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0252235 | PLOS |
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