A novel gold nanoparticle (Do-AuNP) was successfully synthesized from water extracts of traditional Chinese medicine (DO) without using any extra chemicals regents. The physicochemical properties of Do-AuNPs were analyzed by transmission electron microscopy, dynamic light scattering, energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, and atomic force microscopy. The amount of DO extract on the AuNPs was about 13%. In order to evaluate the anti-tumor efficiency and biosafety, the inhibitory rate of HepG2 cells and survival rate of L02 cells were performed , and the immunohistochemical analysis of H&E, Ki-67, and TUNEL staining were conducted . Our results demonstrated that Do-AuNP had better anti-tumor efficiency compared with DO extraction alone without increasing toxicity and . The present study provides useful information for Do-AuNP as a new nanomedicine for liver cancer.
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| http://dx.doi.org/10.1080/10717544.2021.1921079 | DOI Listing |
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