Ticks are obligate hematophagous arthropods that are distributed worldwide and are one of the most important vectors of pathogens affecting humans and animals. Despite the growing burden of tick-borne diseases, research on ticks has lagged behind other arthropod vectors, such as mosquitoes. This is largely because of challenges in applying functional genomics and genetic tools to the idiosyncrasies unique to tick biology, particularly techniques for stable genetic transformations. CRISPR-Cas9 is transforming non-model organism research; however, successful germline editing has yet to be accomplished in ticks. Here, we review the ancillary methods needed for transgenic tick development and the use of CRISPR/Cas9, the most promising gene-editing approach, for tick genetic transformation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8141593 | PMC |
| http://dx.doi.org/10.3389/fcimb.2021.678037 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Molecular Detection of in Ticks Isolated from Domestic Animals in Slaughterhouses and Farms, Shahr-E-Rey, Tehran, Iran.
J Arthropod Borne Dis
June 2024
Department of Vector Biology and Control of Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Background: causes Q fever, a zoonotic and vector-borne disease. Ticks serve as vectors for this bacterium. This study aimed to determine the prevalence of infection in ticks in Shahr-e-Rey County, Tehran Province.
View Article and Find Full Text PDFModeling the Distribution of Dominant Hard Ticks in Southeastern Coastal Areas of the Caspian Sea.
J Arthropod Borne Dis
June 2024
Department of Vector Biology and Control of Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Background: Ticks are hematophagous arthropods that have direct and indirect effects on hosts, including the transmission of pathogens. An environmental suitability study of some vector species of hard ticks was conducted using the MaxEnt model in the south-eastern region of the Caspian Sea in Iran.
Methods: The ticks were collected monthly (2014-2015) at 45 study sites covering different areas in terms of topography.
First report of Haemaphysalis bispinosa, molecular-geographic relationships of Ixodes granulatus and a new Dermacentor species from Vietnam.
Parasit Vectors
January 2025
Department of Parasitology, National Institute of Veterinary Research, Hanoi, Vietnam.
Background: Vietnam and its region are regarded as an ixodid tick biodiversity hotspot for at least two genera: Haemaphysalis and Dermacentor. To contribute to our knowledge on the tick fauna of this country, ticks from these two genera as well as an Ixodes species were analyzed morphologically and their molecular-phylogenetic relationships were examined in taxonomic and geographical contexts.
Methods: For this study, seven Haemaphysalis sp.
Assessing tick attachments to humans with citizen science data: spatio-temporal mapping in Switzerland from 2015 to 2021 using spatialMaxent.
Parasit Vectors
January 2025
Faculty of Geography, Environmental Informatics, University of Marburg, Deutschhausstraße 12, 35032, Marburg, Hessen, Germany.
Background: Ticks are the primary vectors of numerous zoonotic pathogens, transmitting more pathogens than any other blood-feeding arthropod. In the northern hemisphere, tick-borne disease cases in humans, such as Lyme borreliosis and tick-borne encephalitis, have risen in recent years, and are a significant burden on public healthcare systems. The spread of these diseases is further reinforced by climate change, which leads to expanding tick habitats.
View Article and Find Full Text PDFA novel genotype of Babesia microti-like group in Ixodes montoyanus ticks parasitizing the Andean bear (Tremarctos ornatus) in Ecuador.
Exp Appl Acarol
January 2025
Laboratorio de Vectores y Enfermedades Transmitidas, Departamento de Ciencias Biológicas, CENUR Litoral Norte, Universidad de la República, Salto, Uruguay.
Babesia species (Piroplasmida) are hemoparasites that infect erythrocytes of mammals and birds and are mainly transmitted by hard ticks (Acari: Ixodidae). These hemoparasites are known to be the second most common parasites infecting mammals, after trypanosomes, and some species may cause malaria-like disease in humans. Diagnosis and understanding of Babesia diversity increasingly rely on genetic data obtained through molecular techniques.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!