The conservation of chemoselectivity becomes invalid for multiple electrophilic warheads during protein bioconjugation. Consequently, it leads to unpredictable heterogeneous labeling of proteins. Here, we report that a linchpin can create a unique chemical space to enable site-selectivity for histidine and aspartic acid modifications overcoming the pre-requisite of chemoselectivity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8133000 | PMC |
| http://dx.doi.org/10.1039/d1sc00335f | DOI Listing |
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